Author: Yamada, Shinya ; Zaimoku, Yoshitaka ; Hosomichi, Kazuyoshi ; Tomiyama, Yoshiaki ; Hirayasu, Kouyuki ; Tsuji, Noriaki ; Nakao, Shinji ; Sugiyama, Ayana ; Mizumaki, Hiroki ; Kobayashi, Miku ; Sakai, Kazuya ; Ishiyama, Ken ; Tran, Dung Cao ; Hanayama, Rikinari

SummaryWe describe the case of a 74‐year‐old man with severe aplastic anaemia who experienced persistent remission attributed to proliferation of HLA allele‐deficient clones. Despite an initial worsening of pancytopenia with eltrombopag and ciclosporin treatment, gradual trilineage haematopoietic recovery occurred, with blood counts normalizing over 3 years. Flow cytometry and deep nucleotide sequencing revealed that haematopoiesis was primarily supported by several clones with somatic mutations that inactivated antigen presentation via HLA‐A*0206. This suggests that monitoring haematopoietic regeneration by immune escape clones could be an alternative approach for immune aplastic anaemia patients who possess HLA allele‐deficient clones and cannot tolerate standard therapy.

21 Jun 2024·The Journal of Organic Chemistry

Gold-Catalyzed Oxidative Rearrangement Strategy to Yield 2-Hydroxycyclohepta-1,3-diene-1-carbonyl Compounds

Article

Author: Zhu, Jiang ; Yang, Lu ; Li, Jiaji ; Liu, Yongxiang ; Wang, Fudong ; Cheng, Maosheng ; Zhang, Lianjie ; Yan, Jianghao

A gold-catalyzed oxidative rearrangement of propargyl alcohols, derived from commercially available cyclohex-2-en-1-ones and alkynes, was successfully developed for the efficient synthesis of seven-membered rings. Thorough investigations were conducted to optimize the reaction conditions and evaluate its compatibility with various functional groups. Additionally, this methodology was applied to the formal total synthesis of guanacastepene A, demonstrating its practical utility in complex natural product synthesis. This versatile and efficient approach opens up new possibilities for the construction of diverse seven-membered ring systems, providing valuable building blocks for further exploration in drug discovery and the synthesis of intricate molecules.

22 Mar 2024·JCEM Case Reports

Attenuation of Bone Mineral Density Decline During Anemia Treatment With Methenolone Acetate in Myelodysplastic Syndrome

Author: Shiizaki, Kazuhiro ; Sumi, Hirofumi ; Ushimaru, Shu ; Aso, Mea ; Tominaga, Naoto ; Fujishima, Rie

AbstractIn an aging society, addressing the risks and management of osteoporotic fractures is critical to reduce mortality. Similarly, the morbidity of chronic kidney disease and myelodysplastic syndrome increases with aging. The association between chronic kidney disease and fractures is well understood; however, recent reports have indicated an increased risk of incident osteoporosis in patients with prevalent myelodysplastic syndrome. In this case report, we present an older man with stage 4 chronic kidney disease complicated by myelodysplastic syndrome and progressive decline in bone mineral density. He was treated with methenolone acetate and darbepoetin for anemia caused by myelodysplastic syndrome. During anemia treatment, the decline in bone mineral density was attenuated overtime. The case findings suggest the potential association between the use of methenolone acetate as a synthetic anabolic steroid and attenuated decline in bone mineral density.

100 Deals associated with Metenolone Acetate

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KEGG	Wiki	ATC	Drug Bank
D01375	Metenolone Acetate	A14AA04	-

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Indication	Country/Location	Organization	Date
Anemia, Aplastic	Japan	Bayer Yakuhin Ltd.	15 Oct 1962
Osteoporosis	Japan	Bayer Yakuhin Ltd.	15 Oct 1962

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