Delving into the Latest Updates on Q-TIB with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication

Tuberculosis

Inactive Indication-

Originator Organization

Cipla Ltd.

Active Organization

Cipla Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

India (01 Nov 2017),

Tuberculosis

Regulation-

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Author: Nioche, Pierre ; Muller, Laurent ; Soundaramourty, Calaiselvy ; Roger, Claire ; Droit, Arnaud ; Castro, António Gil ; Nicolas, Alexandre ; Cezar, Renaud ; Kundura, Lucy ; Tauzin, Alexandra ; Cruz, André Santa ; André, Sonia ; Estaquier, Jérôme ; Silvestre, Ricardo ; Capela, Carlos ; Claret, Pierre-Géraud ; Carvalho, Alexandre ; Corbeau, Pierre ; Tran, Tu-Anh ; Racine, Gina ; Alleaume-Butaux, Aurélie ; Leclercq, Mickaël ; Mammano, Fabrizio ; Duvnjak, Sandra ; Zghidi-Abouzid, Ouafa ; Sotto, Albert ; Mendes-Frias, Ana ; Pedrosa, Jorge ; Roux-Dalvai, Florence ; Gotti, Clarisse ; Picard, Morgane ; Loubet, Paul ; Lefrant, Jean-Yves

AbstractSevere SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis. By comparing intensive care unit (ICU) and non-ICU COVID-19 patients with age-matched healthy donors, we found a strong positive correlation between plasma levels of soluble FasL (sFasL) and T cell surface expression of Fas/CD95 with the propensity of T cells to die and CD4 T cell counts. Plasma levels of sFasL and T cell death are correlated with CXCL10 which is part of the signature of 4 biomarkers of disease severity (ROC, 0.98). We also found that members of the Bcl-2 family had modulated in the T cells of COVID-19 patients. More importantly, we demonstrated that the pan-caspase inhibitor, Q-VD, prevents T cell death by apoptosis and enhances Th1 transcripts. Altogether, our results are compatible with a model in which T-cell apoptosis accounts for T lymphopenia in individuals with severe COVID-19. Therefore, a strategy aimed at blocking caspase activation could be beneficial for preventing immunodeficiency in COVID-19 patients.

100 Deals associated with Q-TIB

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