An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N -methyl-desformimino derivative of antibiotic LL-AC541.

01 Jan 1972·The Journal of AntibioticsQ4 · MEDICINE

THE ANALYSIS OF A NEW ANTIVIRAL SUBSTANCE S-15-1, STREPTOTHRIGIN GROUP ANTIBIOTIC

Q4 · MEDICINE

Article

Author: Teruhiko Beppu ; Kei Arima ; Takeshi Kawamura

A new antiviral antibiotic S-15-1 was produced by Streptomyces S-15-1 isolated from a soil sample.This product was characterized as a new streptothricin group antibiotic.It exhibited in vitro activity against Newcastle disease virus gram-pos. and gram-neg. bacteria, and some yeasts.A previously described method was used for amino acid autoanal. of S-15-1 and racemomycin hydrolysates.Close agreement was observed with these antibiotics for peaks 1, 2, and 3 corresponding to an amino sugar, β-lysin, and streptolidine, resp.Peak 1 had a somewhat slower mobility than reference D-glucosamine.Neither racemomycin nor S-15-1 produced a component which corresponds to glycine (or N-methyl glycine) which was reported in hydrolyzates of the new streptothricin group antibiotics E-749C, SF-701, and LL-AB 664.The 40-hr hydrolyzate of S-15-1 contained an identified component (peak 2) not observed in racemomycin hydrolyzates.Although it was not possible to resolve the components sufficiently for quant. anal., the data differentiate S-15-1 antibiotic from racemomycin, E-749C, SF-701, and LL-AB664.

01 Jan 1968·The Journal of AntibioticsQ4 · MEDICINE

SF-701, A NEW STREPTOTHRIGIN-LIKE ANTIBIOTIC

Q4 · MEDICINE

Article

Author: Norio Ezaki ; Takashi Tsuruoka ; Taro Niida ; Takashi Shoumura ; Tomizo Niwa

SF-701 was isolated from the culture broth of Streptomyces griseochromogenes and crystallized as the HCl salt, m. 210-3° (decomposition), mol. weight of 570, and [α]24D-68 (c 1, H2O).Elemental analysis indicated a mol. formula of C18H36N7O11·2HCl.SF-701 gave pos. ninhydrin, Fehling, Benedict, Elson-Morgan, and Pauly tests, and neg. FeCl3, biuret, Sakaguchi, and Molisch reactions.SF-701 was active against a wide range of bacteria and resembled a streptothricin antibiotic.

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Infections	Preclinical	Japan	Meiji Seika Pharma Co., Ltd.	01 Jan 1968

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