Last update 04 Jul 2025

HY-0005

Overview

Basic Info

Drug Type
Trispecific T-cell engager (TriTE)
Synonyms
HY 0005, HY0005, HY05350
Target
CD3 x MSLN x PDL1
Action
stimulants, inhibitors
Mechanism
CD3 stimulants(T cell surface glycoprotein CD3 stimulants), MSLN inhibitors(Mesothelin inhibitors), PDL1 inhibitors(Programmed death-ligand 1 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Mesothelin positive Solid TumorsAdvanced Malignant Solid Neoplasm
Inactive Indication-
Originator Organization
Sichuan Huiyu Pharmaceutical Co., Ltd.Sichuan Huiyu Pharmaceutical Co., Ltd.
Active Organization
Sichuan Huiyu Seacross Pharma Technology Ltd.Sichuan Huiyu Pharmaceutical Co., Ltd.Sichuan Huiyu Pharmaceutical Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with HY-0005
CTR20252631
/ Not yet recruitingPhase 1/2
一项评价注射用HY05350在MSLN阳性晚期实体瘤患者中的安全性、耐受性、药代动力学特征和初步临床有效性的多中心、开放标签的I/II期临床研究
[Translation] A multicenter, open-label, Phase I/II clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary clinical efficacy of HY05350 for injection in patients with MSLN-positive advanced solid tumors
100 Clinical Results associated with HY-0005
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100 Translational Medicine associated with HY-0005
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100 Patents (Medical) associated with HY-0005
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100 Deals associated with HY-0005
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Mesothelin positive Solid TumorsPhase 2
China
Sichuan Huiyu Pharmaceutical Co., Ltd.Sichuan Huiyu Pharmaceutical Co., Ltd.
03 Jul 2025
Advanced Malignant Solid NeoplasmIND Approval
China
Sichuan Huiyu Seacross Pharma Technology Ltd.
01 Jul 2025
Solid tumorPreclinical
European Union
Sichuan Huiyu Pharmaceutical Co., Ltd.Sichuan Huiyu Pharmaceutical Co., Ltd.
18 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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