The detection and dosimetry of radiosterilization of pharmaceuticals is a growing concern to numerous government regulatory agencies worldwide. In the absence of suitable detection methods, attention was focused on electron spin resonance (ESR) spectrometry. This paper reports experimental data on ESR dosimetry of irradiated nitrofurans (nitrofurantoin, nifuroxazide, nifurzide and nifurtoinol). Whereas the ESR spectrum of a non-irradiated sample shows no signal, a signal, that is dependent on the irradiation dose is observed with irradiated samples. The number of free radicals was calculated by comparing the second integral from radiosterilized samples and a Bruker strong pitch reference; the values were in the range 1.1 x 10(18)-1.5 x 10(19) radicals mol-1 (G = 0.003-0.03). In addition to qualitative detection, ESR spectrometry can be used for dose determination. When a bi-exponential function is applied to the variation of the peak-to-peak amplitude versus dose, the function correlates well with the data. However, an exponential function, easier to use than a bi-exponential function, will probably be sufficient for dose determination by retrospective dosimetry. Decay of radicals upon storage was modelled using a bi-exponential function. From this, the time limit from the irradiation (25 kGy) for identification of irradiated nitrofurans by ESR can be evaluated. With regard to the commercial aspects of drugs, radicals should be detected up to 2 years after irradiation. The kinetic decrease makes discrimination between irradiated and non-irradiated nitrofurans possible even after storage for up to 2 years, except for nifurtoinol.

01 Dec 1989·Pathologie-biologie

[Inhibition by nifurzide of the adhesion capacity of enteropathogenic colibacillus to HEP-2 cells].

Article

Author: Forestier, C ; Rich, C ; Wash, E ; Darfeuille-Michaud, A ; Cluzel, R ; Joly, B

Enteropathogenic Escherichia coli (EPEC) adhere in vivo to enterocytes. This adhesion capacity can be obtained in vitro with Hep-2 cells on which a characteristic localized adherence (LA) is observed. We studied the effect of subinhibitory concentrations (SIC) of nifurzide, a nitrofurane derivative, on this bacterial adherence phenomenon. Three EPEC strains are used: 11201 (026 serogroup), 7958 (0128) and 7836 (0142). Various SIC (MIC/2; MIC/4;...; MIC/32) were added either to the culture medium of bacteria or to the Eagle medium in which bacteria and Hep-2 cells were mixed during the adhesion experiments. In each case an adhesion index is determined. Nifurzide strongly inhibits the adherence capacity of the three strains when concentrations ranging from MIC/2 to MIC/16 where added in both culture media. On the other hand three other nitrofurane derivatives which have no antibacterial effect did not inhibit adherence. The mechanism of the adherence inhibition by nifurzide is discussed.

01 Dec 1987·Pathologie-biologie

[The role of 4-quinolones and antibiotics in the elimination of virulence plasmids of Enterobacteriaceae].

Article

Author: Sansonetti, P J ; Laporte, J M ; Plesiat, P ; Michel-Briand, Y

Twenty-six antibiotics belonging to thirteen different chemical families had been tested on seven Enterobacteriaceae harbouring a virulence plasmid (Shigella sonnei, S. flexneri, S. dysenteriae, Escherichia coli (two plasmids). Yersinia and Salmonella dublin). Novobiocin and rifampicin were found to be most efficient eliminating three plasmids of which two come from Shigella. Clindamycin, cotrimoxazole, nifurzide, ciprofloxacin, and tilbroquinol were also efficient, but at lower rate. Four virulence plasmids (from the three Shigella sp and Y. pestis) were eliminated by one or several antibiotics. The frequency of elimination was low (at best 10% bacteria per generation). The plasmid pWR105 from S. sonnei was the less stable.

100 Deals associated with Nifurzide

External Link

KEGG	Wiki	ATC	Drug Bank
D07251	Nifurzide	A07AX04	DB13325

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Diarrhea	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis