Last update 25 Oct 2025

HRS-4357

Overview

Basic Info

Drug Type
Small molecule drug, Therapeutic radiopharmaceuticals
Synonyms
HRS 4357, HRS-4357, HRS4357
Target
PSMA
Action
inhibitors
Mechanism
PSMA inhibitors(Prostate-specific membrane antigen inhibitors)
Therapeutic Areas
NeoplasmsUrogenital Diseases
Active Indication
Advanced Prostate CarcinomaPSMA-Positive Prostatic CancerPSMA-Positive Castration-Resistant Prostatic Cancer
Inactive Indication-
Originator Organization
Tianjin Hengrui Pharmaceutical Co., Ltd
Active Organization
Tianjin Hengrui Pharmaceutical Co., Ltd
Inactive Organization
Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with HRS-4357
NCT06006104
/ Unknown statusPhase 1/2
A Phase I/II Clinical Study to Evaluate the Pharmacokinetics, Radiation Dosimetry, Safety and Preliminary Efficacy of HRS-4357 in Patients With PSMA Positive Advanced Prostate Cancer
100 Clinical Results associated with HRS-4357
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100 Translational Medicine associated with HRS-4357
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100 Patents (Medical) associated with HRS-4357
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100 Deals associated with HRS-4357
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Prostate CarcinomaPhase 2-
Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
30 Sep 2023
PSMA-Positive Prostatic CancerPhase 2-
Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
30 Sep 2023
PSMA-Positive Castration-Resistant Prostatic CancerIND Approval
China
Tianjin Hengrui Pharmaceutical Co., Ltd
30 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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