Last update 05 Jul 2025

MK-6592

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MK 6592, VX-667
Target
AURK
Action
inhibitors
Mechanism
AURK inhibitors(Serine/threonine-protein kinase Aurora inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Advanced Malignant Solid NeoplasmSolid tumor
Originator Organization
Vertex Pharmaceuticals, Inc.Vertex Pharmaceuticals, Inc.
Active Organization-
Inactive Organization
Merck Sharp & Dohme Corp.Merck Sharp & Dohme Corp.Merck GmbH
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H26ClF2N7O2
InChIKeySLUHYAXFRJQTGB-KRWDZBQOSA-N
CAS Registry937276-52-3

Related

1
Clinical Trials associated with MK-6592
NCT00359671
/ TerminatedPhase 1
Phase I Study Evaluating MK6592 in Combination With Docetaxel in Adult Patients With Relapsed or Refractory Advanced Solid Tumors
100 Clinical Results associated with MK-6592
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100 Translational Medicine associated with MK-6592
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100 Patents (Medical) associated with MK-6592
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100 Deals associated with MK-6592
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1-
Merck Sharp & Dohme Corp.Merck Sharp & Dohme Corp.
01 Dec 2006
Solid tumorPhase 1
United States
Merck GmbH
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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