Delving into the Latest Updates on Gaxilose with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

4-galactosylxylose, Gaxilosa, LacTEST

Target

β-galactosidase

Action

modulators

Mechanism

β-galactosidase modulators(Beta-galactosidase modulators)

Therapeutic Areas

Congenital DisordersDigestive System DisordersEndocrinology and Metabolic Disease

Active Indication

Lactose Intolerance

Inactive Indication-

Originator Organization

Venter Pharma SL

Active Organization

Venter Pharma SL

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC11H20O10

InChIKeyBYZQBCIYLALLPA-NOPGXMAYSA-N

CAS Registry14087-31-1

The genetic test, LBT, and Gaxilose test measure different physiological aspects such as genetic predisposition, lactose malabsorption, and lactase enzymatic activity, respectively, so the three tests cannot be used interchangeably. Diagnostic bias is introduced by the study's limited use of biopsy confirmation, disregard for secondary hypolactasia, and reliance on genotype as a reference standard.

Results:

Additionally, the clinical validity of the results is compromised by the high variability in genetic polymorphisms across populations, unreported comorbidities like SIBO or IBS, and dubious symptom assessment during testing. Evidence from multicenter studies demonstrates that the Gaxilose test offers high sensitivity and specificity and is well tolerated.

Conclusions:

We conclude that genetic testing alone cannot replace functional or structural assessments and warn that the study's conclusions may lead to misleading diagnostic recommendations in real‐world clinical practice.

01 Apr 2026·NEUROGASTROENTEROLOGY AND MOTILITY

Lactose Breath Test and Genotyping Showed Higher Concordance Than the Urine Gaxilose Test for the Diagnosis of Lactose Malabsorption in Adults

Article

Author: Santander, C. ; Berlanga‐Gómez, M. I. ; Ezquerra‐Durán, A. ; Mancheño‐del Real, V. ; Ferreiros‐Martínez, R. ; Pérez‐Lucendo, I. ; López‐Vega, M. C. ; Fernández‐Pacheco, J. ; Martín‐Dominguez, V. ; Laserna‐Mendieta, E. J. ; Álvarez‐Malé, T. ; Granero‐Cremades, I.

ABSTRACT:

Background:

Lactose malabsorption (LM) is a common condition that occurs when undigested lactose reaches the colon, often causing symptoms such as diarrhea, flatulence, and abdominal pain. Diagnosis can be obtained by performing several tests, each with advantages and disadvantages. This study aims to compare three of the five available methods—the genetic, the urine gaxilose, and the lactose breath tests (LBT) – to evaluate their concordance and assess patient preferences.

Methods:

This is an observational and prospective study from two Spanish hospitals, including 73 adult patients with digestive symptoms and LM suspicion. Alongside the three evaluated methods, the lactose intolerance quick test was performed on duodenal samples in a subgroup of patients. Interpretation of LM was determined based on test concordance. Patient questionnaires were completed once all the tests had been performed.

Results:

There were 71% of female patients, the mean age was 37.6 years, and 52% showed LM. The patients with LM more commonly displayed nausea or vomiting ( p = 0.039), avoidance of dairy products ( p = 0.023), and use of analgesic and/or anti‐inflammatory drugs ( p = 0.016). Higher concordance among tests was found in patients without LM (83%), compared to 53% in patients with LM, due to false negatives (32%) for the gaxilose test. All tests showed over 90% sensitivity, with LBT displaying the highest (97%). Genetic testing showed the highest specificity (95%) and the gaxilose test the lowest (68%). Among the three tests, 72% of patients preferred the genetic test.

Conclusions:

The LBT and genetic tests showed higher concordance than gaxilose for detecting LM.

01 Apr 2025·FOOD CHEMISTRY

Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages

Article

Author: Xu, Junren ; Yuan, Yong ; Zhu, Mingzhi ; Zhao, Mengmeng ; Yin, Feiyan ; Liu, Zhonghua ; Zhao, Yiqiao ; Chao, Jin ; Wang, Kunbo ; Li, Na ; Huang, Jianan

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.

100 Deals associated with Gaxilose

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