100 Clinical Results associated with Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products)
100 Translational Medicine associated with Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products)
100 Patents (Medical) associated with Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products)
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Literatures (Medical) associated with Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products)01 Jan 2009·Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
[Pharmacokinetics of PEG recombinant human interleukin-6 in rats].
Article
Author: Yang, Guang ; Yin, Hai-Lin ; He, Xue-Ling ; Zhang, Xue-Me
OBJECTIVE:To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.
METHODS:Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.
RESULTS:PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.
CONCLUSION:The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG.
100 Deals associated with Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products)