[Translation] A single-center, randomized, double-blind, placebo-controlled, single-ascending dose clinical trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SYH2068 injection in healthy Chinese participants with elevated lipoprotein (a)
主要目的:评价SYH2068注射液在Lp(a)升高健康参与者中单次皮下注射给药的安全性和耐受性
次要目的:评价SYH2068注射液在Lp(a)升高健康参与者中单次皮下注射给药的PK、PD特征;评价SYH2068注射液在Lp(a)升高健康参与者中单次皮下注射给药对QT/QTc间期的影响;评价SYH2068注射液在Lp(a)升高健康参与者中单次皮下注射给药的免疫原性特征。
[Translation] Primary objective: To evaluate the safety and tolerability of a single subcutaneous injection of SYH2068 injection in healthy participants with elevated Lp(a)
Secondary objectives: To evaluate the PK and PD characteristics of a single subcutaneous injection of SYH2068 injection in healthy participants with elevated Lp(a); To evaluate the effect of a single subcutaneous injection of SYH2068 injection on the QT/QTc interval in healthy participants with elevated Lp(a); To evaluate the immunogenicity characteristics of a single subcutaneous injection of SYH2068 injection in healthy participants with elevated Lp(a).