Delving into the Latest Updates on Natural Killer (NK) Cells(The People's Hospital of Dazu, Chongqing) with Synapse

Overview

Basic Info

Drug Type

Natural Killer Cell Therapies

Synonyms

Natural Killer Mixture(The People's Hospital of Dazu, Chongqing)

Target-

Action-

Mechanism-

Therapeutic Areas

NeoplasmsDigestive System Disorders

Active Indication

Colorectal Cancer

Inactive Indication-

Originator Organization

The People's Hospital of Dazu, Chongqing

Active Organization

The People's Hospital of Dazu, Chongqing

Inactive Organization-

License Organization-

Drug Highest PhaseClinical

First Approval Date-

Regulation-

This work describes a highly efficient route to an orthogonally protected α-galactosylphytosphingosine (α-GalPhyt) from which 6″-N-modified α-galactosylceramide (α-GalCer) analogues can be synthesized rapidly and on-scale. Key to this route is the use of a d-galactal-derived 1,2-anhydro donor that undergoes an α-selective glycosylation with a sphingoid acceptor. The resulting α-GalPhyt intermediate can be orthogonally deprotected, enabling selective manipulation at either the C-6″ position of the galactose ring or at C-2 of the sphingoid lipid. The utility of this approach was demonstrated by the synthesis of the potent natural killer (NK) T cell agonist, NU-α-GalCer, and a novel 6″-amino-6″-deoxy analogue of another notable agonist, 7DW8-5, both from the same key intermediate.

100 Deals associated with Natural Killer (NK) Cells(The People's Hospital of Dazu, Chongqing)

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