Abstract3‐Allyl‐5‐(4‐arylazo)‐2‐thioxothiazolidine‐4‐one (HLn) ligands (where n = 1 to 3) were hypothesized to have antimicrobial activities mediated through inhibition of new antimicrobial targets. The ligands (HLn) were synthesized and characterized by infrared (IR) and 1H nuclear magnetic resonance (1H NMR) spectra. The ligands (HLn) were in silico screened to their potential inhibition to models of d‐alanyl carrier protein ligase (DltA) (from Bacillus cereus, PDB code 3FCE) and nucleoside diphosphate kinase (NDK) (from Staphylococcus aureus; PDB code 3Q8U). HL3 ligand has the best energy and mode of binding to both NDK and DltA, even though its binding to DltA was stronger than that to NDK. In antimicrobial activity of HL3 ligand, morphological and cytological changes in HL3‐treated bacteria agreed with the in silico results. The HL3 ligand showed significant antimicrobial activity against B. cereus, S. aureus, and Fusarium oxysporium. The HL3‐treated bacterial cells appeared malformed and incompletely separated. Its cell walls appeared electron‐lucent and ruptured. They contained more mesosomes than normal cells. It was found that the HL3 ligand represented as a bactericide against B. cereus and S. aureusby blocking target DltA, and may target NDK.

01 Oct 2010·Ying yong sheng tai xue bao = The journal of applied ecology

[Screening, identification, and biocontrol effect of antagonistic bacteria against Phytophthora capsici].

Article

Author: Shen, Qi-rong ; Zhao, Qing-yun ; Mei, Xin-lan ; Shen, Biao ; Xu, Yang-chun ; Tan, Shi-yong

A total of 98 isolates with antagonistic activity against Phytophthora capsici were isolated from the rhizosphere soil of healthy pepper plants in the fields seriously infected by pepper Phytophthora capsicit, and two strains named as HL-3 and LZ-8 were screened, which had the characteristics of wide-spectrum antagonism and good growth under poor soil condition. The HL-3 and LZ-8 were identified as Paenibacillus polymyxa and Bacillus pumilus, respectively, based on their morphological and biochemical characteristics and 16S rDNA sequences. The two strains could inhibit the mycelium growth of P. capsici, and the inhibitory effect of HL-3 and LZ-8 was 72% and 68%, respectively. The two strains also had antifungal activities toward other plant pathogens such as Verticillium dahliae, Fusarium oxysporum f. sp. cucumerinum, F. oxysporum f. sp. vasinfectum, Rhizoctonia solani, Phtophthora parasitica var. nicotiana, and Ralstonia solanacearum. Pot experiment showed that the biocontrol effects of HL-3 and LZ-8 against P. capsici at the seedling stage of pepper were 72% and 83%, respectively, and both of the strains had significant growth-promoting effect on pepper plants.

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Neoplasms	Phase 1	CN	Shanghai Kechow Pharma, Inc.Startup	-
Stroke	Preclinical	CN	Shanghai Kechow Pharma, Inc.Startup	-

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