Four new piericidin rhamnosides (2, 4-6) together with three known piericidins (1, 3, 7) were isolated from the culture broth of the unidentified actinomycete strain TMPU-A0287 as potentiators of antifungal amphotericin B (AmB) activity. The structures of piericidins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 2 and 4-6 possessed a ketone at C-10 and one or two methoxy groups on the rhamnose in their structures. Compounds 1-7 did not exhibit antifungal activity against Candida albicans and all potentiated AmB activity. The MIC values of AmB against C. albicans combined with 1-7 (4.0 μg ml^-1) decreased from 0.50 to 0.063 or 0.031 μg ml^-1, yielding an 8- or 16-fold increase in AmB activity.

01 Jan 2013·Open Journal of Medicinal Chemistry

Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348

Author: Shimada, Kanako ; Fukumoto, Atsushi ; Ishihara, Ryo ; Anzai, Yojiro ; Ooka, Kazuhiro ; Kato, Fumio ; Yamanaka, Tomoe

Piericidin A1, 3'-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp.QS is well known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence, biofilm formation, swarming motility, antibiotic biosynthesis and virulence factor productionC. violaceum CV026 is commonly used to determine qual. and quant. QS activity.The structures of piericidin derivatives were characterized, and their QS activities were determined

01 Jan 1996·The Journal of AntibioticsQ4 · MEDICINE

New Piericidin Antibiotics, 7-Demethylpiericidin A1 and 7-Demethyl-3'-rhamnopiericidin A1.

Q4 · MEDICINE

Article

Author: Kimura, Ken-ichi ; Miyata, Nobuo ; Yoshihama, Makoto ; Takahashi, Hidetoshi ; Uramoto, Masakazu

The isolation, structures, and biol. properties of 2 new antibiotics of the piericidin family, SN-198-D (I) and SN-198-B (II), are reported.I and II were purified from the fermentation broth of Streptomyces SN-198 and their structures were confirmed to be 7-demethylpiericidin A₁ and 7-demethyl-3'-rhamnopiericidin A₁, resp., by UV, IR, NMR, and mass spectroscopy.I and II exhibited antimicrobial and antitumor activities.Some structure-activity correlations among I, II, piericidin A₁ (SN-198-E), and 3'-rhamnopiericidin A₁ (SN-198-C) were established.

100 Deals associated with SN-198C

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	Japan	Snow Brand Milk Products Co., Ltd.	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

SN-198C

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation