Nrf2 modulators(Nuclear factor erythroid 2-related factor 2 modulators), STAT3 modulators(Signal transducer and activator of transcription 3 modulators)

Therapeutic Areas

NeoplasmsImmune System DiseasesNervous System Diseases+ [4]

Active Indication

Polycystic Ovary SyndromeAutoimmune DiseasesUveitis+ [1]

Inactive Indication-

Originator Organization-

Active Organization

Tianjin Medical University

Second Hospital of Tianjin Medical University

Shahid Chamran University of Ahvaz

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC7H10O4

InChIKeyZWWQRMFIZFPUAA-UHFFFAOYSA-N

CAS Registry617-52-7

100 Clinical Results associated with Dimethyl itaconate

100 Translational Medicine associated with Dimethyl itaconate

100 Patents (Medical) associated with Dimethyl itaconate

1,301

Literatures (Medical) associated with Dimethyl itaconate

01 Oct 2025·Talanta

Dimethyl itaconate: An effective antioxidant for promoting angiogenesis under oxidative stress

Article

Author: Liu, Suzhen ; Liu, Yicong ; Zhang, Miaomiao ; Song, Chunli ; Tang, Jilin ; Li, Zongjia

Angiogenesis is an important physiological process in the human body. When ischemic diseases occur, the ischemic and hypoxic environment induces excessive production of reactive oxygen species (ROS) within cells, which inhibits angiogenesis and leads to poor prognosis. Therefore, finding antioxidants that can eliminate excessive ROS to promote angiogenesis is crucial for the treatment of ischemic diseases. In this work, we investigate the antioxidant effects of dimethyl itaconate (DMI) by using an oxidative stress model in human umbilical vein endothelial cells (HUVECs). Our results demonstrate that DMI significantly reduces excessive ROS in cells under oxidative stress. DMI could protect mechanical properties of HUVECs from oxidative stress. The Young's modulus of HUVECs was 10.0 ± 1.4 kPa after treatment with H₂O₂. However, the Young's modulus increased to 24.42 ± 1.4 kPa when HUVECs were co-incubated with H₂O₂ and DMI (40 μg mL^-1). DMI also maintained cell morphology and cytoskeletal integrity. Meanwhile, DMI alleviates mitochondrial dysfunction by enhancing mitochondrial membrane potential (MMP) and increasing adenosine triphosphate (ATP) levels. The excellent antioxidant effects of DMI result from upregulating the expression levels of superoxide dismutase 2 and catalase, significantly leading to the removal of intracellular excessive ROS. With protecting HUVECs from oxidative stress damage, DMI promotes cell migration and angiogenesis. Consequently, this work not only elaborates on the mechanism by which DMI promotes angiogenesis by anti-oxidative stress, but also provides a new therapeutic option for the treatment of ischemic diseases.

15 Apr 2025·Chinese Journal of Chemistry

1‐Methylpyridine‐2(1H)‐thione Photocatalyzed Giese Reaction with N‐Hydroxyphthalimide Esters via Single Electron Transfer

Author: Tang, Xinjun ; Wang, Yuzhuo ; Yuan, Li ; Li, Lanting

Comprehensive SummaryWe have developed a series of 1‐methylpyridine‐2(1H)‐thione (MPT) analogues to be used as organocatalysts. The MPT catalysts are easily prepared and bench‐stable. In our previous work, we found that the ground‐state MPT catalyst could act as a nucleophile to generate primary radicals via an SN2 pathway. However, this reaction was limited to benzyl radicals. Herein, we reported a new catalytic property of the MPT catalyst. The photoexcited MPT catalyst (E(MPT·+/MPT*) = –1.60 V vs. Ag/AgCl in MeCN) could reduce NHPI esters through a single electron transfer process. Various carbon radicals, including benzyl radical, as well as primary, secondary and tertiary alkyl radicals, could be generated easily. Notably, amino acids, peptide, pharmaceuticals, and other biologically active molecules could be modified by using this methodology showing the potential synthetic utility of this method.

11 Apr 2025·ACS Applied Polymer Materials

Enhanced Properties of 3D-Printed Graphene Oxide Nanocomposites through Itaconic Acid Polyester Grafting

Author: Maturi, Simone ; Milani, Paolo ; Maturi, Mirko ; Migliorini, Lorenzo ; Benelli, Tiziana ; Molina, Sergio Ignacio ; Giorgini, Loris ; de la Mata, María ; Comes Franchini, Mauro ; Sanz de León, Alberto

Vat photopolymerization (VP) is a powerful additive manufacturing process to produce high-resolution 3D objects from liquid photocurable resins, but the mech. performance of its standard materials restricts its use in high-demanding applications.In this study, graphene oxide (GO), a widely investigated nanomaterial, was surface-functionalized by grafting the sustainable and photocurable poly(butylene itaconate-co-adipate) (PBIA) polyester to address these limitations.The covalent grafting of PBIA significantly improved the colloidal stability and dispersibility of GO in photocurable formulations, eliminating the need for extensive homogenization during the formulation of the nanocomposite resin.PBIA-coated GO (GO@PBIA) was easily miscible with VP resins, enabling the fabrication of 3D-printed nanocomposites with superior mech. properties.At low filler concentrations (0.05 wt %), the GO@PBIA composites increased their elastic modulus up to 57% and tensile strength up to 100% compared to the base polymer, outperforming analogous composites prepared with unmodified GO.Surface modification also enhanced the deformability of the matrix, making these composites suitable for applications under tensile and flexural loads.Optical and morphol. analyses confirmed the homogeneous distribution of GO@PBIA within the polymer matrix, demonstrating improved filler-matrix interactions, while elec. conductivity measurements proved that the surface modification approach proposed does not affect the conductive conjugated π system of the nanomaterial.This work highlights the potential of polymer-grafted GO as a multifunctional nanofiller to enhance the mech. properties and processability of VP-based materials, paving the way for their use in high-performance applications.

100 Deals associated with Dimethyl itaconate

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Polycystic Ovary Syndrome	Preclinical	Iran	Shahid Chamran University of Ahvaz	01 Oct 2024
Autoimmune Diseases	Preclinical	China	Second Hospital of Tianjin Medical University	06 Apr 2024
Autoimmune Diseases	Preclinical	China	Tianjin Medical University	06 Apr 2024
Uveitis	Preclinical	China	Second Hospital of Tianjin Medical University	06 Apr 2024
Uveitis	Preclinical	China	Tianjin Medical University	06 Apr 2024
Pain	Preclinical	Iran	Shahid Chamran University of Ahvaz	01 Apr 2024

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