Oxaprozin

Abstract: Highly enantioselective construction of axially chiral cyclohexylidenes is difficult and challenging due to their structural peculiarities.The development of efficient method for the assembly of novel axially chiral cyclohexylidenes becomes particularly important in axial chirality.Chiral allylborons have become a focus of interest in chem. community as an important synthon as well as a backbone structure, yet an efficient and practical synthetic method for the synthesis of axially chiral allylborons have not been disclosed so far.Herein, we report a copper-catalyzed strategy which could readily access enantiopure axially chiral allylborons under mild conditions.The obtained axially chiral allylborons can also be subjected to a number of subsequent transformations as well as late modification of drug mols., thus demonstrating the validity of the developed method.

The development of sustainable and efficient catalytic systems for the formation C—C, C—N, C—O bonds is a fundamental goal in modern synthetic chemistry. We present a biomass‐derived Cu/Chitosan‐800 catalyst that facilitates a range of carbenoid insertion reactions into C—H, N—H, and O—H bonds. This catalyst demonstrates remarkable activity, enabling the functionalization of diverse substrates, including the late‐stage modification of drug molecules with up to 95% yield and good recyclability. Our findings highlight the catalyst's potential in advancing environmentally friendly chemical transformations, offering a promising tool for pharmaceutical synthesis and organic synthesis.