Last update 04 Apr 2026

Dirocaftor/Nesolicaftor/Posenacaftor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diponecaftor, PTI-428/PTI-808/PTI-801, PTI-NC-733
Target
CFTR
Action
stimulants
Mechanism
CFTR stimulants(Cystic fibrosis transmembrane conductance regulator stimulants)
Therapeutic Areas
Congenital DisordersDigestive System DisordersRespiratory Diseases+ [1]
Active Indication
Cystic Fibrosis
Inactive Indication-
Originator Organization
Proteostasis Therapeutics, Inc.Proteostasis Therapeutics, Inc.
Active Organization
University Medical Center of UtrechtUniversity Medical Center of Utrecht
Inactive Organization
Proteostasis Therapeutics, Inc.Proteostasis Therapeutics, Inc.
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC27H27NO5
InChIKeyQUDOHCFOJCNKPK-QGZVFWFLSA-N
CAS Registry2095064-05-2
View All Structures (3)

Related

100 Clinical Results associated with Dirocaftor/Nesolicaftor/Posenacaftor
Login to view more data
100 Translational Medicine associated with Dirocaftor/Nesolicaftor/Posenacaftor
Login to view more data
100 Patents (Medical) associated with Dirocaftor/Nesolicaftor/Posenacaftor
Login to view more data
100 Deals associated with Dirocaftor/Nesolicaftor/Posenacaftor
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 2
Belgium
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
France
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Germany
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Italy
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Netherlands
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Portugal
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Spain
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
Sweden
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Cystic FibrosisPhase 2
United Kingdom
University Medical Center of UtrechtUniversity Medical Center of Utrecht
03 Jun 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free