Last update 16 May 2025

S-1746

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
S 1746, SB 737005, SB-737005
Target
AMPA receptor x NMDA receptor
Action
antagonists, modulators
Mechanism
AMPA receptor antagonists(Glutamate receptor ionotropic AMPA antagonists), NMDA receptor modulators(Glutamate [NMDA] receptor modulators)
Therapeutic Areas
Nervous System DiseasesCardiovascular Diseases
Active Indication-
Inactive Indication
Acute Ischemic Stroke
Originator Organization
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
Active Organization-
Inactive Organization
GSK PlcGSK PlcShionogi & Co., Ltd.Shionogi & Co., Ltd.
License Organization
GSK PlcGSK PlcShionogi & Co., Ltd.Shionogi & Co., Ltd.
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC14H8N6O4
InChIKeyADPHGDUUADGFSX-UHFFFAOYSA-N
CAS Registry251919-00-3

Related

100 Clinical Results associated with S-1746
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100 Translational Medicine associated with S-1746
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100 Patents (Medical) associated with S-1746
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100 Deals associated with S-1746
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Ischemic StrokePhase 1
United States
GSK PlcGSK Plc
31 Mar 2003
Acute Ischemic StrokePhase 1
Japan
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
31 Mar 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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