β-Cypermethrin (β-CYP), a synthetic pyrethroid pesticide, is widely used for insect management. However, it also affects non-target organisms and pollutes aquatic ecosystems. Tetrahymena thermophila, a unicellular ciliated protist found in fresh water, is in direct contact with aquatic environments and sensitive to environmental changes. The proliferation of T. thermophila was inhibited and the cellular morphology changed under β-CYP stress. The intracellular ROS level significantly increased, and SOD activity gradually rose with increasing β-CYP concentrations. Under 25 mg/L β-CYP stress, 687 genes were up-regulated, primarily enriched in the organic cyclic compound binding and heterocyclic compound binding pathways. These include 8 ATP-binding cassette transporters (ABC) family genes, 2 cytochrome P450 monooxygenase genes, and 2 glutathione peroxidase related genes. Among of them, ABCG14 knockdown affected cellular proliferation under β-CYP stress. In contrast, overexpression of ABCG14 enhanced cellular tolerance to β-CYP. The results demonstrated that Tetrahymena tolerates high β-CYP concentration stress through various detoxification mechanisms, with ABCG14 playing a crucial role in detoxification of β-CYP.

01 Dec 2024·Pest Management Science

Control efficacy and joint toxicity of broflanilide mixed with commercial insecticides to an underground pest, the black cutworm in highland barley

Article

Author: Lu, Hui ; Duan, Fenglei ; Wang, Ying ; Chen, Yiqu ; Tang, Tao ; Wang, Yingnan ; Zhao, Chunqing ; Zhan, Enling

AbstractBACKGROUNDThe highland barley, Hordeum vulgare L., is a staple food crop with superior nutritional functions in Xizang, China. It is often damaged by the black cutworm, Agrotis ipsilon (Hufnagel), which is an underground pest and difficult to effectively manage. To introduce a novel insecticide with unique mode of action, broflanilide (BFL) and its binary mixtures with chlorantraniliprole (CAP), fluxametamide, β‐cypermethrin or imidacloprid were screened out as seed treatment to control black cutworm in highland barley in the present study.RESULTSIn the laboratory bioassays, BFL had outstanding insecticidal activity to black cutworm with a median lethal dose (LD50) of 0.07 mg kg−1. The mixture of BFL × CAP at the concentration ratio of 7:40 exhibited the highest synergistic effect with a co‐toxicity coefficient of 280.48. In the greenhouse pot experiments, BFL and BFL × CAP seed treatments at 8 g a.i. kg−1 seed could effectively control black cutworm, with a low percentage of injured seedlings <20% and high control efficacies of 93.33–100% during a period of 3–12 days after seed emergence. Moreover, BFL and BFL × CAP seed treatments could promote the seed germination and seedling growth of highland barley at the tested temperatures of 15, 20 and 25 °C.CONCLUSIONOur results indicated that BFL and BFL × CAP were effective and promising insecticides as seed treatment to control black cutworm in highland barley. © 2024 Society of Chemical Industry.

01 Dec 2024·Food Chemistry

Hexafluoroisopropanol-based supramolecular solvent for liquid phase microextraction of pesticides in milk

Article

Author: Li, Xiaoyun ; Gong, Wenwen ; Wang, Fang ; Li, Hui ; Yao, Zhiliang ; Addo, Tay Seyram Nana ; Zhang, Yuchen ; Jiang, Shanxue ; Li, Dandan

Residues of pesticides in milk may pose a threat to human health. This study aimed to develop a liquid-phase microextraction (LPME) method using hexafluoroisopropanol (HFIP)-based supramolecular solvent (SUPRAS) for the simultaneous extraction and purification of four pesticides (boscalid, novaluron, cypermethrin and bifenthrin) in milk. Pesticides were extracted using SUPRAS prepared with nonanol and HFIP, and the extraction efficiency was analyzed. Results showed satisfactory recoveries ranging from 80.8%-111.0%, with relative standard deviations (RSDs) of <6.4%. Additionally, satisfactory linearities were observed, with correlation coefficients >0.9952. The limits of quantification (LOQs) were in the range of 1.8 μg·L^-1-14.0 μg·L^-1. The established method demonstrated high extraction efficiency with a short operation time (15 mins) and low solvent consumption (2.7 mL). The HFIP-based SUPRAS LPME method offers a convenient and efficient approach for the extraction of pesticides from milk, presenting a promising alternative to conventional techniques.

News (Medical) associated with Cypermethrin

13 Aug 2024

·www.drugs.com

Pesticide Exposure Tied to Increased Risk for Stillbirth

TUESDAY, Aug. 13, 2024 -- Pesticide exposures during preconception and the first trimester may be associated with stillbirth, according to a study published online July 16 in the American Journal of Epidemiology . Melissa A. Furlong, Ph.D., from the University of Arizona College of Public Health in Tucson, and colleagues linked Arizona pesticide use records (27 types) with birth certificates (2006 to 2020) to estimate associations between living within 500 m of any application site and stillbirth. The researchers found that during 90 days preconception, any exposures to pesticides were associated with stillbirth, including cyfluthrin (relative risk [RR], 1.97), zeta-cypermethrin (RR, 1.81), organophosphates as a class (RR, 1.60), malathion (RR, 2.02), carbaryl (RR, 6.39), and propamocarb hydrochloride (RR, 7.72). During the first trimester, fenpropathrin (RR, 4.36), permethrin (RR, 1.57), organophosphates as a class (RR, 1.50), acephate (RR, 2.31), and formetanate hydrochloride (RR, 7.22) were associated with stillbirth. "These findings underscore the importance of considering individual pesticides rather than just the overall pesticide class, as specific chemical compounds may pose unique risks," Furlong said in a statement. "It also highlights the potential for prepregnancy exposures to affect reproductive outcomes." One author disclosed ties to pesticide registrants unrelated to the research.

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