Delving into the Latest Updates on Benoxinate Hydrochloride/Fluorescein Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Fluorescent dyes

Synonyms

Altafluor benox

Target

SCNA

Action

modulators

Mechanism

SCNA modulators(Sodium voltage-gated channel alpha subunits modulators)

Therapeutic Areas

Other Diseases

Active Indication

AnesthesiaOphthalmologic surgical procedures

Inactive Indication-

Originator Organization

Altaire Pharmaceuticals, Inc.

Active Organization

Altaire Pharmaceuticals, Inc.Bausch + Lomb Ireland Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (14 Dec 2017),

Ophthalmologic surgical procedures

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaC17H29ClN2O3

InChIKeyPRGUDWLMFLCODA-UHFFFAOYSA-N

CAS Registry5987-82-6

View All Structures (2)

We compared the potential for bacterial contamination of a proparacaine hydrochloride solution preserved with benzalkonium chloride, which is used with fluorescein paper for tonometry, to that of a fluorescein-benoxinate hydrochloride combination solution preserved with chlorobutanol. We contaminated bottles of each solution with Pseudomonas aeruginosa or Staphylococcus aureus (10(7) organisms per milliliter of eyedrop solution). From the fluorescein-benoxinate hydrochloride solution, Staphylococcus organisms were cultured in declining numbers over time, with a half-life of nine seconds, and no Staphylococcus organisms were recovered after five minutes. Pseudomonas organisms disappeared from this solution within 15 seconds. Neither species was viable after 15 seconds in the proparacaine hydrochloride solution. Additionally, we cultured 12 bottles of fluorescein-benoxinate hydrochloride and 15 bottles of proparacaine hydrochloride that had been in use in the clinic for one month. No organisms were recovered from a drop dispensed from any bottle or from the tips, caps, rims, or solution from within any bottle, except that five colonies of Staphylococcus grew from the external rim of one bottle. We conclude that both solutions sterilize themselves rapidly and effectively. Either may be used safely for tonometry.

100 Deals associated with Benoxinate Hydrochloride/Fluorescein Sodium

Login to view more data

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Anesthesia	United States	Bausch + Lomb Ireland Ltd.	09 Mar 2020
Ophthalmologic surgical procedures	United States	Altaire Pharmaceuticals, Inc.	14 Dec 2017

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01959230 (CTgov)	Phase 3	Hyperemia \| Erythema	60	Brimonidine Tartrate+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate)	dvnvhfdsni(alpnzvfurm) = zkxhpjyllz jposdpfdki (rqsrmujfni, coobmtfjhf - qzvtyzbxim) View more	-	23 Oct 2019
				Vehicle+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate Vehicle)	dvnvhfdsni(alpnzvfurm) = nrvppavqax jposdpfdki (rqsrmujfni, fexwypcazr - kypqrfghew) View more
NCT01959243 (CTgov)	Phase 3	Hyperemia	507	Brimonidine Tartrate+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate)	jsobenhoyd(odshtpvbey) = okzsstbsna chbieqzgbf (amrqsfkcyo, alnzhsmwzh - hntgtzidog) View more	-	23 Oct 2019
				Vehicle+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate Vehicle)	jsobenhoyd(odshtpvbey) = qvzdlzsbyj chbieqzgbf (amrqsfkcyo, sitrkaspzb - mifhjsqaww) View more