Delving into the Latest Updates on Calcium Lactate Hydrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-Hydroxypropanoic acid calcium salt, Calcium 2-hydroxypropanoate (1:2), Calcium Laclate

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Target-

Mechanism

Calcium supplements

Therapeutic Areas

Endocrinology and Metabolic DiseaseSkin and Musculoskeletal Diseases

Active Indication

OsteomalaciaOsteoporosis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC3H6O3

InChIKeyJVTAAEKCZFNVCJ-UHFFFAOYSA-N

CAS Registry50-21-5

View All Structures (2)

Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design: Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution (150; 75; 0 mM Ca-lactate) is immediately followed by a standard fluoride rinse.
Procedure: Rinses are performed in the evening. The rinse combinations are given in a random order, and the subjects are unaware of the sequence. At least 3 days separates the use of each rinse. Dosage: 20 mL and 1 minute rinse with each solution.
Saliva samples: Twelve hours after rinsing, unstimulated saliva samples are collected by expectoration.
Analysis: The fluoride concentration in saliva samples are analysed Statistics and data handling: Fluoride in saliva 12 hours after rinsing are examined by one-way ANOVA, repeated measures design.

Start Date01 Oct 2011

Sponsor / Collaborator

Karolinska Institutet

NCT00172172 / CompletedPhase 3

A Study to Evaluate the Effects of Calcium Supplementation on the Efficacy and Safety of Recombinant Human Parathyroid Hormone (ALX1-11) in Postmenopausal Women With Osteoporosis (CAP Study)

This study is evaluating the effects of calcium supplementation on the efficacy and safety of recombinant parathyroid hormone (ALX1-11) in postmenopausal women with osteoporosis. The primary objective of this clinical study is to evaluate whether increases in bone mineral density (BMD) for subjects treated with ALX1-11 and receiving no calcium supplementation are less than increases in BMD observed for subjects treated with ALX1-11 and receiving calcium supplementation.

Start Date10 Jan 2004

Sponsor / Collaborator

Shire Plc

100 Clinical Results associated with Calcium Lactate Hydrate

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100 Translational Medicine associated with Calcium Lactate Hydrate

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100 Patents (Medical) associated with Calcium Lactate Hydrate

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378

Literatures (Medical) associated with Calcium Lactate Hydrate

01 Jan 2025·Food Chemistry

Role of calcium salts in modulating benzo[a]pyrene levels in barbecued pork sausages: A study on quality attributes and safety

Article

Author: Ding, Honglie ; Xu, Baocai ; Zhou, Hui ; Lu, Jingnan ; Cai, Kezhou ; Hu, Manzi ; Mei, Hebao

Benzo[a]pyrene (BaP), known for its carcinogenic and mutagenic properties, is a marker of polycyclic aromatic hydrocarbons (PAHs). This study aimed to investigate the effect of partially replacing sodium chloride with different calcium salts (calcium chloride, calcium gluconate, calcium citrate, and calcium lactate) on BaP formation in barbecued pork sausages. The results revealed that all four calcium salts inhibited BaP formation in barbecued pork sausages (P < 0.05). Specifically, calcium gluconate showed the most significant effect on BaP inhibition, with an inhibition rate of 61.82 %. Furthermore, calcium salts were found to inhibit lipid oxidation in barbecued pork sausages while promoting the Maillard reaction. Further validation experiments used resveratrol and sodium sulfite as lipid oxidation and Maillard reaction inhibitors, respectively. These results indicated that lipid oxidation is the primary pathway for BaP production in barbecued pork sausage and that the addition of calcium salts can effectively block this process.

01 Nov 2024·Pediatric Exercise Science

Acute Response of Calcium Lactate Supplementation on the Athletic Performance of Soccer Players Under the Age of 15

Article

Author: Azevedo, Vitor ; Azevedo, Paulo ; Azevedo, Henrique ; Padilha, Daniel ; Loturco, Irineu ; Artioli, Guilherme ; Santos, David

Purpose: To determine the acute response of lactate supplementation on athletic performance. Method: Fifteen athletes under the age of 15 performed the following 4 sessions in a nonrandomized order: (1) familiarization, (2) control, (3) participants ingested calcium lactate (21.5 mg·kg−1 body mass), and (4) participants ingested a placebo (PLA, calcium carbonate, 21.5 mg·kg−1 body mass). The capsules were randomly offered and consumed 60 minutes before the physical tests. To assess the physical performance, the athletes executed squat jump, countermovement squat jump, 20-m linear sprint, change of direction test, and running anaerobic sprint test. Results: There were no significant differences between conditions for squat jump, countermovement jump, change of direction, and minimum power obtained in the running anaerobic sprint test (P > .05). Conversely, we observed a worse performance (P < .05) in the 20-m linear sprint test in the PLA and lactate conditions compared with control (P < .05). The lactate condition worsened performance during running anaerobic sprint test for peak power, mean power, and fatigue index compared with control and PLA (P < .05). Conclusions: Calcium lactate supplementation worsened repetitive running sprint ability and 20-m sprint performance. However, lactate supplementation does not affect jump or agility capacity. Therefore, calcium lactate supplementation seems to be an ineffective strategy to improve anaerobic and neuromuscular performance in soccer players 15 years of age or less.

29 Oct 2024·ACS Omega

Storage Potential of Cactus Mucilage Powder for Incorporation into Foods and Production of Biopolymeric Films

Article

Author: Silva, Thieres George Freire da ; Silva, Lúcio José Vieira ; Silva, Ivo Diego de Lima ; Brito, Andréa Monteiro Santana Silva ; Souza, Jheizon Feitoza do Nascimento ; Vinhas, Glória Maria ; Simões, Adriano do Nascimento ; Andrada, Lucas Vinícius Pierre de ; Martins, Lady Daiane Costa de Sousa

The objective was to investigate the physicochemical stability of stored cactus pear mucilage and assess the technological feasibility to produce polymeric films. Mucilage of cactus pear species Nopalea cochenillifera (L.) Salm-Dyck MIU and Opuntia stricta (Haw.) Haw-OEM was extracted and stored for 2, 4, 6, 8, and 10 months in the absence of light at a temperature of 26.5 °C and relative humidity of 41.3%. At each storage time, polymeric films were produced using hydrated mucilage (4%, weight-w/volume-(v)), glycerol (60%, v/v), and calcium lactate (2%, w/v). Among the species, MIU stood out due to its higher water and oil retention, but it also presented higher levels of phenolic compounds, and more intense peaks in Fourier transform infrared spectrophotometry (FTIR) analysis. On the other hand, OEM is richer in carbohydrates, denser, and electrically conductive. The characteristics highlighted for each species are also observed in the principal component analysis (PCA). Both species are equally soluble in water, and more than 60% of their granules have a diameter of 250 mm. The resulting films of MIU exhibited increased resistance and permeability but were less soluble and transparent. Microscopically, greater homogeneity was observed, and the films were thicker, whitish, and thermally stable. Both species have the potential for producing polymeric films with various applications in the food industry, particularly as edible coatings.

100 Deals associated with Calcium Lactate Hydrate

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