HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists), MAGEA1 inhibitors(Melanoma-associated antigen 1 inhibitors), TERT inhibitors(Telomerase reverse transcriptase inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication

Solid tumor

Originator Organization

VAXON Biotech SA

Active Organization

VAXON Biotech SA

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

Clinical Trials associated with Vx-006

NCT02289196 / CompletedPhase 1

A Multicenter, Open Label, Uncontrolled Phase I Trial to Compare Safety, Tolerability and Immunogenicity of Vx-006 Vaccine at 0.5mg, 1mg, 5mg and 10mg Doses in Human Leukocyte Antigen-A02 (HLA-A02) Positive Patients With Solid Tumours

Patients with histologically proven malignancy with documented disease control (objective response or stable disease) or Not Evaluable Disease (NED) expectancy > 6 months; only HLA-A*02 positive patients.
The primary objective of the trial is to compare safety and tolerability of four different doses of Vx-006. The secondary objective is to compare immunogenicity of four different doses of the Vx-006.

Start Date01 Mar 2014

Sponsor / Collaborator

VAXON Biotech SA

100 Clinical Results associated with Vx-006

100 Translational Medicine associated with Vx-006

100 Patents (Medical) associated with Vx-006

Literatures (Medical) associated with Vx-006

01 Oct 2000·Food and Chemical ToxicologyQ2 · MEDICINE

Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells

Q2 · MEDICINE

Article

Author: N.Y Kim ; D.H Sohn ; Y.C Kim ; S.J Lee ; W.G Ko ; T.H Kang ; B.H Lee

Three polymethoxyflavonoids from the fruit of Vitex rotundifolia, namely 2',3',5-trihydroxy-3,6,7-trimethoxyflavone (Vx-1), vitexicarpin (Vx-5) and artemetin (Vx-6), were tested for their antiproliferative activity in human myeloid leukemia HL-60 cells. They showed a dose-dependent decrease in the growth of HL-60 cells. The concentrations required for 50% inhibition of the growth (IC50) after 96 h were 4.03 microM, 0.12 microM and 30.98 microM for Vx-1, Vx-5 and Vx-6, respectively. Treatment of HL-60 cells with the flavonoids induced morphological changes that are characteristic of apoptosis. We judged the induction of apoptosis by the detection of DNA fragmentation in agarose gel electrophoresis and the degree of apoptosis was quantified by a double-antibody sandwich ELISA and by flow cytometric analysis. The C-3 hydroxyl and C-8 methoxyl groups were found not to be essential for the activity, but the C-3' methoxyl instead of hydroxyl group lowered the antiproliferative and apoptosis inducing activity. These results suggest that the polymethoxyflavonoids isolated from V. rotundifolia may be used as potential chemopreventive and chemotherapeutic agents.

100 Deals associated with Vx-006

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Phase 2	-	VAXON Biotech SA	-
Solid tumor	Phase 1	GR	VAXON Biotech SA	01 Mar 2014

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