Delving into the Latest Updates on Furfuryl biguanide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Mechanism

Insulin sensitizers

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication-

Inactive Indication

Diabetes Mellitus, Type 2

Originator Organization

Chugai Pharmaceutical Co., Ltd.

Active Organization-

Inactive Organization

Chugai Pharmaceutical Co., Ltd.

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

Structure

Molecular FormulaC7H11N5O

InChIKeyWXIHLCZQQGEOKH-UHFFFAOYSA-N

CAS Registry7644-42-0

Primary Objective:
The primary objective of this study is to assess the overall safety of lixisenatide once daily treatment in combination with background oral anti-diabetic treatment over 52 weeks in patients with type 2 diabetes in Japan.
Secondary Objective:
To assess the effects of lixisenatide in combination with background oral antidiabetic drug (OAD) on:
HbA1c;
Fasting plasma glucose;
Body weight.

Start Date01 Sep 2013

Sponsor / Collaborator

Sanofi

JPRN-UMIN000010624 / CompletedIIT

Vildagliptin and biguanide on postprandial blood glucose and vascular endothelial function in type 2 diabetic patients with coronary artery disease - VIBRATE-J study

Start Date01 Apr 2013

Sponsor / Collaborator-

JPRN-UMIN000005266 / SuspendedIIT

Effects of thiazolidinedione and biguanide in groups divided according to diabetic pathophysiology - Effects of thiazolidinedione and biguanide in groups divided according to diabetic pathophysiology

Start Date01 Apr 2011

Sponsor / Collaborator-

100 Clinical Results associated with Furfuryl biguanide

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100 Translational Medicine associated with Furfuryl biguanide

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100 Patents (Medical) associated with Furfuryl biguanide

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37

Literatures (Medical) associated with Furfuryl biguanide

01 Aug 2022·Pest Management ScienceQ1 · AGRICULTURAL & FORESTRY SCIENCE

Identification and functional analysis of a chemosensory protein from Bactrocera minax (Diptera: Tephritidae)

Q1 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Wang, Guirong ; Liu, Yipeng ; Cui, Zhongyi ; Zhou, Qiong

AbstractBackgroundOlfaction has an indispensable role in insect behavior, enabling location of suitable host plants and oviposition sites, finding mates and evasion of natural enemies. Chemosensory proteins (CSPs) function to screen external odorants and transport them to olfactory receptor neurons, thereby increasing the sensitivity of the olfactory system. At present, CSP genes have been identified in many insect species, but there are relatively few studies on the function of CSP, especially in Tephritidae.ResultsIn this study, we sequenced and analyzed 12 transcriptomes of Bactrocera minax and identified five CSP genes. The results of polymerase chain reactions with reverse transcription showed that BminCSP3 was highly expressed only in antennae. Results from competitive binding experiments showed that BminCSP3 has good binding ability to citral compared with 23 other volatile organic compounds. The docking model with citral showed hydrogen bond formation with residues (ARG97); however, no hydrogen bonds were formed in the docking of five other ligands (furfuryl alcohol, linalool, cis‐3‐hexenyl acetate, (R)‐(+)‐limonene and (+)‐carvone). Electroantennogram (EAG) analyses revealed that citral was active in B. minax at the antennal level, and the EAG response value of female adults was significantly higher than that of male adults. Furthermore, the results of behavioral bioassays showed that females were significantly attracted to citral.ConclusionOur results suggest that BminCSP3 plays an important role in the recognition of citral by B. minax adults. © 2022 Society of Chemical Industry.

01 Oct 2020·Bioresource TechnologyQ1 · ENGINEERING & TECHNOLOGY

One-pot biosynthesis of furfuryl alcohol and lactic acid via a glucose coupled biphasic system using single Bacillus coagulans NL01

Q1 · ENGINEERING & TECHNOLOGY

Article

Author: Zheng, Zhao-Juan ; Yan, Yu-Xiu ; Bu, Chong-Yang ; Ouyang, Jia ; Zou, Li-Hua

Furfuryl alcohol is an important reduction product from biomass derived furfural. This study developed one-pot biosynthesis of furfuryl alcohol and lactic acid by a glucose coupled biphasic system using single Bacillus coagulans NL01. Water/dioctyl phthalate is chosen as biphasic system to alleviate the toxicity of furfural and furfuryl alcohol. Under the optimal conditions, the high-concentration conversion (208 mM) of furfural was successfully converted in 6 h reaction with 98% furfural conversion and 88% furfuryl alcohol selectivity. Notably, glucose as co-substrate could be effectively converted to lactic acid in this biphasic system. About 264 mM furfuryl alcohol and 64.2 g/L lactic acid were simultaneously produced from 310 mM furfural and 71.3 g/L glucose within 8.5 h by a fed-batch strategy. The developed approach can not only increase the produced furfuryl alcohol concentration but also reduce the cost of overall approach by lactic acid co-production, indicating its potential for industrial applications.

01 Sep 2020·International Journal of Women's Dermatology

Oxidative stress as a treatment target in atopic dermatitis: The role of furfuryl palmitate in mild-to-moderate atopic dermatitis

Article

Author: Hebert, Adelaide A

100 Deals associated with Furfuryl biguanide

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