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Last update 08 May 2025

Benzobarbital

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Benzonal

Target

GABAA receptor

Action

agonists

Mechanism

GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)

Therapeutic Areas

Nervous System Diseases

Active Indication

Epilepsy

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC19H16N2O4

InChIKeyQMOWPJIFTHVQMB-UHFFFAOYSA-N

CAS Registry744-80-9

100 Clinical Results associated with Benzobarbital

100 Translational Medicine associated with Benzobarbital

100 Patents (Medical) associated with Benzobarbital

301

Literatures (Medical) associated with Benzobarbital

01 Mar 2022·Chromatographia

Practical Evaluation of Chitosan-Based Chiral Stationary Phase for Pharmaceutical Analysis by High-Performance Liquid Chromatography

Author: Bai, Zheng-Wu ; Gao, Ya-Ya ; Tang, Sheng ; Liang, Shuang ; Chen, Wei

In the recent years, the resolution of drug enantiomers has received widespread attention in the medical field.It is of great practical significance to develop an efficient chiral separation material for drug anal.Based on the distinct advantages of both favorable separation performance and good solvent tolerance, chitosan bis(4-methylphenylcarbamate)-(isobutylurea) was chosen as a chiral selector for enantioseparation of a series of chiral drugs in this work.It was found that most of the tested chiral drugs were recognized with certain drug enantiomers being effectively resolved under the conventional normal phase chromatog. conditions without any mobile phase additive; thus, indicating that the proposed method is promising for practical application in pharmaceutical anal., which may lay a foundation for the study on pharmacokinetics and pharmacodynamics of drug enantiomers.

01 Aug 2019·Electroanalysis

Electrochemical Characterization and Voltammetric Determination of Benzoyl Derivatives of Phenobarbital Using Glassy Carbon Electrode

Author: Arbit, Galina ; Filimonov, Victor ; Mikheeva, Elena ; Slepchenko, Galina ; Mezentseva, Olga

AbstractThe electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6‐311+G method. It is established that the process is quasi‐reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

01 Apr 2018·Chromatographia

Comparative Enantiomer-Resolving Ability of Coated and Covalently Immobilized Versions of Two Polysaccharide-Based Chiral Selectors in High-Performance Liquid Chromatography

Author: Nino Takaishvili ; Bezhan Chankvetadze ; Eka Tsutskiridze ; Nino Beridze ; Tivadar Farkas

The separation of enantiomers of over 175 randomly selected chiral acidic, basic, and neutral compounds was studied on 4 polysaccharide-based chiral columns made by coating or covalent attachment of cellulose 3,5-dichlorophenylcarbamate or amylose 3,5-dimethylphenylcarbamate on the surface of silica.Triscarbamate derivatives of cellulose or amylose were used for the preparation of coated-type columns, while in the case of covalently immobilized chiral stationary phases, the resp. polysaccharides were not completely carbamoylated but only close to triscarbamates.This minimal difference in the chem. composition of the polysaccharide derivatives resulted in significantly different enantiomer-resolving ability for certain groups of chiral compounds while only marginally different for other chiral analytes.This p.d. between coated- and covalently immobilized versions of the "same" chiral selector must be considered in method development with these columns, as well as in method transfer between them.

100 Deals associated with Benzobarbital

External Link

KEGG	Wiki	ATC	Drug Bank
-	Benzobarbital	N03A	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Epilepsy	-	-	-

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