Delving into the Latest Updates on AL-310 with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Hypertension

Originator Organization

Trifermed SL

Active Organization-

Inactive Organization

Trifermed SL

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC60H94N8O14S2

InChIKeyKSVUDIVDMLGFHN-UHFFFAOYSA-N

CAS Registry534576-69-7

The binding of N-substituted aminocarboxylic acid dicyclohexylamide (NACA-DCHA) derivatives to M-1 muscarinic cholinoreceptors (MRs) in rat brain cortex and and beta-1 adrenoreceptors (ARs) in rat heart was studied. The maximum MR affinity was observed for AL-275 (IC50, 2.8 microM) and AL-315 (IC 50, 3.2 microM) preparations. The other compounds (except AL-310 with IC50 > 100 microM) interacted with MR at a lower affinity. The binding to beta-1 AR in rat heart was observed for a single preparation AL-298 (IC50, 38 microM). The antimuscarinic activity of some NACA-DCHA derivatives, especially AL-275 and AL-315) may play a significant role in realization of the antiarrhythmic activity.

Eksperimental'naya i Klinicheskaya Farmakologiya

Binding of derivatives of N-substituted aminocarboxylic acid dicyclohexylamides to muscarinic cholinoreceptors and β-adrenoreceptors

Author: Brusova, E. G. ; Kaverina, N. V. ; Likhosherstov, A. M.

The binding of N-substituted aminocarboxylic acid dicyclohexylamide (NACA-DCHA) derivatives to M-1 muscarinic cholinoreceptors (MRs) in rat brain cortex and β-1 adrenoreceptors (ARs) in rat heart was studied.The maximum MR affinity was observed for AL-275 (IC₅₀, 2.8 μM) and AL-315 (IC 50, 3.2 μM) preparationsThe other compounds (except AL-310 with IC₅₀ > 100 μM) interacted with MR at a lower affinity.The binding to β-1 AR in rat heart was observed for a single preparation AL-298 (IC₅₀, 38 μM).The antimuscarinic activity of some NACA-DCHA derivatives, (especially AL-275 and AL-315) may play a significant role in realization of the antiarrhythmic activity.

100 Deals associated with AL-310

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