Last update 14 Dec 2024

GB-5005

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-CD19 CAR-T cells - Shanghai Genechem, Anti-CD19 chimeric antigen receptor T cell therapy - Shanghai Genechem, GB 5005
+ [2]
Target
CD19
Mechanism
CD19 modulators(B-lymphocyte antigen CD19 modulators)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases
Active Indication
B lymphoblastic leukemia lymphoma
Inactive Indication
B-Cell LeukemiaB-Cell LymphomaCD19 Positive B-Cell Leukemia+ [2]
Originator Organization
Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.
Active Organization
Shanghai Genbase Biotechnology Co. Ltd.Shanghai Genbase Biotechnology Co. Ltd.
Inactive Organization
Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.
Drug Highest PhaseIND Approval
First Approval Date-
Regulation-
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Related

7
Clinical Trials associated with GB-5005
ChiCTR2000035631 / SuspendedEarly Phase 1IIT
A multi-center, randomized, open-label clinical controlled study of autologous CD19 CAR-T cells alone and its sequential ASCT in the treatment of relapsed and refractory B-cell lymphoma
ChiCTR2000033480 / RecruitingEarly Phase 1IIT
Safety, tolerability, effectiveness and pharmacokinetics characteristic clinical research of intensive pretreatment combined with GB5005 chimeric antigen receptor T cell injection in the treatment of patients with CD19-positive relapsed / refractory B-cell non-Hodgkin's lymphoma (B-NHL)
ChiCTR2000030159 / RecruitingEarly Phase 1IIT
The Safety, Tolerance and PK Clinical Study of GB5005 Chimeric Antigen Receptor T Cells in the Treatment of Paediatric Patients With CD19 Positive Relapse/Refractary B Cell Acute Lymphoblastic Leukemia
100 Clinical Results associated with GB-5005
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100 Translational Medicine associated with GB-5005
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100 Patents (Medical) associated with GB-5005
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100 Deals associated with GB-5005
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
B-Cell LymphomaPhase 1
CN
Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.
15 Aug 2020
Pre B-cell acute lymphoblastic leukemiaPhase 1
CN
Shanghai Genbase Biotechnology Co. Ltd.Shanghai Genbase Biotechnology Co. Ltd.
04 Feb 2020
B-Cell LeukemiaPhase 1
CN
Shanghai Genbase Biotechnology Co. Ltd.Shanghai Genbase Biotechnology Co. Ltd.
30 Sep 2019
Systemic Lupus ErythematosusPhase 1
CN
Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.
01 Mar 2017
CD19 Positive B-Cell LeukemiaPhase 1
CN
Shanghai Genechem Co., Ltd.Shanghai Genechem Co., Ltd.
28 Dec 2015
B lymphoblastic leukemia lymphomaIND Approval
CN
Shanghai Genbase Biotechnology Co. Ltd.Shanghai Genbase Biotechnology Co. Ltd.
23 Sep 2022
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Clinical Result

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Approval

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Regulation

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