Delving into the Latest Updates on Tampramine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Tampramine Fumarate, 富马酸坦帕明

Target

NET

Mechanism

NET inhibitors(Norepinephrine transporter inhibitors)

Therapeutic Areas

Other Diseases

Active Indication-

Inactive Indication

Depressive Disorder

Originator Organization

Pfizer Inc.

Active Organization-

Inactive Organization

Pfizer Inc.

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure

Molecular FormulaC27H28N4O4

InChIKeyUSQAILMOWHOBTK-WLHGVMLRSA-N

CAS Registry83166-18-1

View All Structures (2)

The effect of acute administration of AHR-9377 on performance under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule was assessed. AHR-9377 reduced response rates and increased reinforcement rates of rats responding under the DRL 72-s schedule; these effects were similar to those of established antidepressant drugs. AHR-9377 also decreased the time of immobility in the forced-swimming test, an empirical model of depression. These results are consistent with the contention that AHR-9377 possesses antidepressant activity.

01 Oct 1984·Biochemical PharmacologyQ2 · MEDICINE

Neurochemical properties of AHR-9377: A novel inhibitor of norepinephrine reuptake

Q2 · MEDICINE

Article

Author: Robin D. Tabor ; Laura Y. Norrell ; William J. Kinnier

A novel potential antidepressant, AHR-9377, was evaluated for its inhibition of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) reuptake in hypothalmic, cortical, and striatal rat synaptosomal preparations. AHR-9377 was found to be a potent, selective, noncompetitive inhibitor of NE reuptake. In addition, repeated injections of AHR-9377 caused a decrease in the density of beta adrenergic receptors in rat cerebral cortex. Little displacement by AHR-9377 at beta, alpha 1 and alpha 2 adrenergic, histaminergic, muscarinic, GABA-ergic, benzodiazepine of imipramine sites was observed. These pharmacological properties indicate that AHR-9377 may have clinical antidepressant activity with few side effects.

100 Deals associated with Tampramine

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