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Last update 08 May 2025

Butamben

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

4-Aminobenzoic acid butyl, Butamben (USP), Butyl aminobenzoate

+ [2]

Target

VDCCs

Action

blockers

Mechanism

VDCCs blockers(Voltage-gated calcium channel blockers)

Therapeutic Areas

Nervous System DiseasesSkin and Musculoskeletal DiseasesOther Diseases

Active Indication

AnesthesiaPainPruritus

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC11H15NO2

InChIKeyIUWVALYLNVXWKX-UHFFFAOYSA-N

CAS Registry94-25-7

100 Clinical Results associated with Butamben

100 Translational Medicine associated with Butamben

100 Patents (Medical) associated with Butamben

597

Literatures (Medical) associated with Butamben

01 Jun 2025·Journal of Industrial and Engineering Chemistry

Magnetically separable iron oxide nanoparticle for reduction of nitroarenes and reductive amination of carbonyl compounds in aqueous medium

Author: Aggarwal, Varun ; Saima ; Singh, Hemant ; Selvaraj, Manickam ; Bala, Ekta ; Kachore, Ankit ; Verma, Praveen Kumar ; Suleiman, Mohamed Hammad Adam

Novel biogenic iron oxide nanoparticles (Fe@BNPs) were synthesized using Adiantum capillus-veneris extract (aqueous) as a capping and stabilizing agent and meticulously characterized using FT-IR, UV-vis, FESEM, EDX, TEM, XPS, and XRD techniques.Subsequently, Fe@BNPs were employed for the catalytic reduction of various nitroarom. compounds employing hydrazine hydrate under benign reaction conditions in water.Notably, the magnetic behavior of Fe@BNPs enabled their facile recovery using an external magnet, facilitating catalyst reuse in multiple cycles with minimal leaching or loss of activity.Furthermore, the versatility of Fe@BNPs was demonstrated through their application in reductive amination reactions, employing nitro-reduced primary amines and carbonyl compoundsThis ligand-free approach offers significant advantages including environmental sustainability, green solvent, exceptional product yields, straightforward workup procedures, efficient purification, gram-scale reactions and excellent catalyst reusability.

01 Jun 2025·Journal of Molecular Structure

Self-assemblies of two ring salicylaldimine at low temperatures: Mesophase behaviour and DFT investigations

Author: Nakum, Kiran J. ; Joshi, Vijay K. ; Geres, Marium ; Katariya, Kanu ; Hagar, Mohamed ; Joshi, Richa ; Wani, Tanveer ; Bhatt, Ronak

In the area of liquid crystalline compounds, development of low temperature liquid crystals (LTLCs) remained stimulating.One of the significant challenges in the development of LTLCs is maintaining stability in the desired liquid crystalline phase while preventing crystallization at low temperaturesIn this context, the present manuscript describes the synthesis of a series of new LCs (n-alkyl 4-((4-decyloxy)-2 hydroxy benzylidene)amino)benzoates, bearing two rings linked by imine linkage.One aromatic ring carries decyloxy chain while the other carries ester moiety with systematically varied alkoxy chains.New mols. revealed enantiotropic smectic-A behavior below 117°C studied initially by POM and confirmed by DSC anal.Further, the VT-XRD showed the parallel mol. arrangement of SmA phase.Addnl., computational analyses using D. Functional Theory were conducted to investigate aspect ratio, dipole moment, mol. polarizability and their correlation with thermal stability.Mol. electrostatic potential mapping was applied to understand the influence of alkoxy chain length on distribution of charges and interactions between mols.Frontier MOs anal. provided insights into HOMO-LUMO energy levels, chem. hardness (η) and global softness (S).These combined exptl. and computational approaches will facilitate a deeper understanding of the structure-property relationships that govern the mesomorphic behavior of salicylaldimine liquid crystals, with a focus on optimizing mol. design for advanced liquid crystalline applications.

09 Apr 2025·Chemistry – A European Journal

Asymmetric Amination of 1,2‐Diol through Borrowing Hydrogen: Synthesis of Vicinal Amino α‐Tertiary Alcohol

Article

Author: Khan, Ajmal ; Rahman, Tahir ; Perveen, Shahida ; Wang, Lingyun ; Ali, Tariq

AbstractMethods to prepare vicinal amino alcohols are important because of their presence in biologically active compounds. Despite the development of various methods for vicinal amino alcohol synthesis, C(sp3)‐rich oxygen‐containing β‐amine compounds continue to pose great challenge. While ring‐opening reaction of epoxides with amine nucleophile is the prime method for vicinal amino alcohol preparation, epoxides are highly reactive and sometimes difficult to make, resulting in drawbacks regarding selectivity of this approach. Here, we report a catalytic enantio‐convergent amination of α‐tertiary 1,2‐diols for the efficient access to vicinal amino α‐tertiary alcohols. The racemic α‐tertiary 1,2‐diol substrates of different alkyl/aryl or alkyl/alkyl backbone, can be converted to chiral vicinal amino α‐tertiary alcohols through diphenyl phosphate‐mediated RuCl3 catalysed asymmetric borrowing hydrogen (ABH) pathway. This simple ABH reaction can be scaled up to the synthesis of chiral ligands, synthetic intermediates, and other medicinally‐relevant compounds. Overall, this catalytic redox‐neutral procedure broadens the scope of Ru‐catalysed amination of alcohols and discloses an underexplored step‐ and atom‐economical synthetic strategy for the synthesis of vicinal amino α‐tertiary alcohols and provides a practicable alternative to the present benchmark procedures.

100 Deals associated with Butamben

External Link

KEGG	Wiki	ATC	Drug Bank
D00730	Butamben	D04AB	DB11148

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anesthesia	-	-	-
Pain	-	-	-
Pruritus	-	-	-

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