Last update 27 Oct 2025

SIM-0508

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SIM 0508, SIM0508
Target
POLQ
Action
inhibitors
Mechanism
POLQ inhibitors(DNA polymerase theta inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmSolid tumorLocally Advanced Malignant Solid Neoplasm+ [1]
Inactive Indication-
Originator Organization
Simcere Pharmaceutical Group Ltd.Simcere Pharmaceutical Group Ltd.
Active Organization
Shanghai Xianxiang Medical Technology Co., Ltd.Simcere Pharmaceutical Group Ltd.Simcere Pharmaceutical Group Ltd.Jiangsu Simcere Pharmaceutical Co., Ltd.Jiangsu Simcere Pharmaceutical Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SIM-0508
NCT06686745
/ RecruitingPhase 1
A Phase I, First-in-Human, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0508 Monotherapy and Combination Therapy in Adult Participants With Locally Advanced/Metastatic Solid Tumors
100 Clinical Results associated with SIM-0508
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100 Translational Medicine associated with SIM-0508
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100 Patents (Medical) associated with SIM-0508
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100 Deals associated with SIM-0508
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
China
Shanghai Xianxiang Medical Technology Co., Ltd.
27 Nov 2024
Solid tumorIND Approval
United States
Simcere Pharmaceutical Group Ltd.Simcere Pharmaceutical Group Ltd.
29 Aug 2024
Locally Advanced Malignant Solid NeoplasmIND Approval
China
Shanghai Xianxiang Medical Technology Co., Ltd.
22 Aug 2024
Metastatic Solid TumorIND Approval
China
Shanghai Xianxiang Medical Technology Co., Ltd.
22 Aug 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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