Sulfadoxine

NEW YORK and BAAR, Switzerland, Aug. 1, 2023 /PRNewswire/ -- Vyera Pharmaceuticals, LLC ("Vyera") and Phoenixus AG ("Phoenixus") today announced that they have entered into an Asset Purchase Agreement related to Daraprim and Vecamyl. The aggregate consideration to be paid for the sale and transfer of the purchased assets and the assignment of the certain contracts, subject to adjustment, shall be $650,000 together with the assumption of post-closing liabilities. The closing of the transaction is subject to satisfaction of certain conditions, including without limitation approval of the United States Bankruptcy Court for the District of Delaware with which Vyera and Phoenixus, together with affiliated parties, have filed voluntary petitions for relief under Chapter 11 of Title 11 of the United States Code and have elected to proceed under Subchapter V thereunder. The bankruptcy cases are jointly administered under Case No. 23-10605 (JKS). As part of the Subchapter V proceedings, Vyera filed a motion seeking authorization of its proposed bidding procedures under which to conduct its 363 sale. Additional information about this process and the proposed asset sale, as well as other documents relating to Vyera's Subchapter V proceedings, is available through Vyera's claims and noticing agent's website: . DLA Piper LLP is serving as the Vyera's legal counsel. SierraConstellation Partners LLC is serving as Chief Restructuring Officer and financial advisor, and Alvarez and Marsal Securities LLC is serving as investment banker. For more information about the sale process, interested parties should contact Alvarez and Marsal Securities LLC. About Daraprim DARAPRIM is a prescription medication that contains pyrimethamine for the treatment of toxoplasmosis when used with a sulfonamide (e.g., sulfadoxine). Toxoplasmosis is a serious, sometimes fatal infection caused by the Toxoplasma gondii (T. gondii) parasite, one of the most common parasites in the world. About Vecamyl VECAMYL® (mecamylamine HCI) is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. About Vyera Vyera is a United States based biopharmaceutical company committed to developing and commercializing treatments that address serious and rare diseases with high unmet medical needs. Vyera supports programs that offer financial assistance to patients in need and gives discounts to organizations that provide care to underserved populations. Vyera's research and development efforts focus on novel treatment options for toxoplasmosis and other rare or serious health conditions. . About Phoenixus AG Phoenixus AG is a Swiss based global biopharmaceutical enterprise using a virtual pharma and centralized services development model to reduce the risk, costs and timing of product development across its portfolio companies. Forward-Looking Statements This press release contains certain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and as that term is defined in the Private Securities Litigation Reform Act of 1995, that involve risks, uncertainties, and assumptions that are difficult to predict. Buyer and Vyera and Phoenixus (collectively, the "Companies") intend that such forward-looking statements be subject to the safe harbors created thereby. Words and expressions reflecting optimism, satisfaction or disappointment with current prospects, as well as words such as "believes," "hopes," "intends," "estimates," "expects," "projects," "plans," "anticipates" and variations thereof, or the use of future tense, identify forward-looking statements, but their absence does not mean that a statement is not forward-looking. The Companies' forward-looking statements are not guarantees of performance, and actual results could vary materially from those contained in or expressed by such statements due to risks and uncertainties including: (i) the sufficiency of the Companies' cash position, (ii) the Companies' ability to raise additional capital to fund its operations, (iii) the Companies' ability to meet its debt obligations, if any, (iv) the Companies' ability to enter into partnership or licensing arrangements with third parties, (v) the Companies' ability to identify patients to enroll in its clinical trials in a timely fashion, (vi) the Companies' ability to achieve approval of a marketable product, (vii) the design, implementation and conduct of the Companies' clinical trials, (viii) the results of the Companies' clinical trials, including the possibility of unfavorable clinical trial results, (ix) the market for, and marketability of, any product that is approved, (x) the existence or development of vaccines, drugs, or other treatments that are viewed by medical professionals or patients as superior to the Companies' products, (xi) regulatory initiatives, compliance with governmental regulations and the regulatory approval process, (xii) general economic and business conditions, (xiii) changes in foreign, political, and social conditions, and (xiv) various other matters, many of which are beyond the Companies' control. Except as required by law, neither Company undertakes any responsibility to update any forward-looking statements to take into account events or circumstances that occur after the date of this press release. Media Contact [email protected] SOURCE Vyera Pharmaceuticals

Researchers at the University of Georgia used hepatocytes to develop the first medium-throughput, 384-well plate-based liver-stage antimalarial drug discovery platform Westbury, NY – February 25, 2021 – BioIVT, a leading provider of research models and services for drug and diagnostic development, today announced that it is hosting a webinar at 11 a.m. ET on March 4 that will describe how primary hepatocytes are being used to screen small molecule drugs for activity against the Plasmodium parasites that cause malaria. There were an estimated 229 million cases of malaria worldwide in 2019, and an estimated 409,000 malaria deaths, according to the World Health Organization (WHO).1 Children under five years of age are the most vulnerable, accounting for 67% of malaria deaths worldwide in 2019.1 Malaria parasites have developed resistance to many early antimalarial drugs. For example, Plasmodium falciparum exhibits multi-drug resistance to chloroquine, sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine. Resistance to artemisinin has also recently emerged in parts of Southeast Asia.2 This ongoing issue, which dramatically impacts malaria control efforts, underscores why continuing research in this area is so important. In humans, malaria parasites grow and multiply first in the liver cells and later in the red blood cells. It is the blood stage parasites that cause the symptoms of malaria.3 During this webinar, Dr. Steven Maher, an associate research scientist in the Center for Tropical and Emerging Global Diseases Department at the University of Georgia, will outline how his team used primary human hepatocytes to develop the first medium-throughput, 384-well plate-based liver-stage antimalarial drug discovery platform. As these hepatocytes can mimic liver properties, they allow his team to evaluate the metabolism, drug-drug interaction, and toxicity of drug candidates in addition to their impact on parasite load. Dr. Maher has a unique scientific background. He is an expert both in Plasmodium culture techniques, which are applicable throughout the parasite’s lifecycle (blood, mosquito, and liver stages), and complex hepatocyte culture models. Dr. Maher began his drug discovery career as a Fellow in the Draper Laboratory, where microelectromechanical systems (MEMS) technology was developed, and later used to create a liver-on-a-chip to study malaria liver stage invasion. Using this technology, Dr. Maher’s team was able to determine the optimal conditions for culturing the liver stages of Plasmodium in primary human hepatocyte cultures. That breakthrough enabled them to develop their liver-stage antimalarial drug discovery platform, which they are now using to screen novel compounds. “We are delighted to have this opportunity to highlight Dr. Maher’s work and his techniques for culturing Plasmodium parasites. Information like this is of great benefit to the scientific community as researchers explore new approaches to safely and effectively treat malaria and address that unmet medical need,” said Scott Heyward, Director, R&D and Scientific Affairs, BioIVT. During his webinar, Dr. Maher will discuss the drug discovery platform, review complex and multiplex in vitro systems for primary hepatocyte culture, describe how to assess primary hepatocytes lots to determine their suitability for Plasmodium infection, and outline next steps in understanding the Plasmodium lifecycle. Interested persons can register for this complimentary webinar, entitled “Identifying the Critical Factors Enabling a Phenotypic Screen for Small Molecule Activity Against Plasmodium Parasites Developing in Primary Human Hepatocytes,” at . BioIVT offers a broad range of products for in vitro infectious disease research. They include large lots of highly viable, consistent cryopreserved human hepatocytes, and cynomolgus and rhesus hepatocytes, which have been isolated to increase their robustness and reliability in plated assays. The increased availability of these hepatocytes helps researchers develop new drugs for hepatic infectious diseases and ADME Tox models. BioIVT’s metabolically active HEPATOPAC® cultures are also used for long-term infectious disease models because they respond very similarly to in vivo conditions. Further information about these products is available at . References WHO Malaria Fact Sheet. November 30, 2020. Centers for Disease Control and Prevention (CDC) Drug Resistance in the Malaria-Endemic World. CDC Malaria Biology. About BioIVT BioIVT is a leading global provider of research models and value-added research services for drug discovery and development. We specialize in control and disease-state biospecimens including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. And as the premier supplier of hepatic products, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and their effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in elevating science. For more information, please visit or follow the company on Twitter @BioIVT. # # #