Delving into the Latest Updates on Paclitaxel/Cisplatin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

TP

Target

DNA x Tubulin

Action

inhibitors

Mechanism

DNA inhibitors(DNA inhibitors), Tubulin inhibitors, DNA alkylating agents

Therapeutic Areas

Neoplasms

Active Indication

Locally Advanced Head and Neck Squamous Cell Carcinoma

Inactive Indication-

Originator Organization

Tianjin Medical University Cancer Institute and Hospital

Active Organization

Tianjin Medical University Cancer Institute and Hospital

Inactive Organization-

License Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC47H51NO14

InChIKeyRCINICONZNJXQF-MZXODVADSA-N

CAS Registry33069-62-4

View All Structures (2)

Because pregnant women have been excluded from clinical research, including tuberculosis (TB) research, little is known about diagnosing, treating and preventing TB in pregnant women. We plan to perform a two-stage randomized trial that will identify best practices for screening pregnant and postpartum women for active TB (screening by symptoms vs. C-reactive protein levels) and the optimal timing of TPT initiation, relative to pregnancy (immediately during pregnancy or deferred to postpartum). Because undiagnosed TB among pregnant women with HIV is associated with many devastating complications to both the mother and fetus, this research has the potential to improve maternal and birth outcomes worldwide.

Start Date01 Jun 2026

Sponsor / Collaborator

The University of California, San Francisco

[+2]

NCT06713057

/ Not yet recruitingPhase 2IIT

Precision Medicine Applied to Locally Advanced or Metastatic Poorly Differentiated or Anaplastic Thyroid Cancer Using Tumor Derived Organoids and In-vitro Sensitivity Testing: a Phase 2, Single-center, Open-label, and Non-comparative Study

The current study aims to explore the potential advantages of chemotherapy that is implemented based on drug sensitivity testing. This pertains to individuals with locally advanced or metastatic poorly differentiated or anaplastic thyroid cancer who have undergone conventional therapy in the past or unresectable patients .

Start Date01 Dec 2024

Sponsor / Collaborator

West China Hospital

NCT06636981

/ RecruitingPhase 2IIT

All Trans Retinoic Acid Combined with Toripalimab+Chemotherapy for Locally Advanced Inoperable or Metastatic Triple Negative Breast Cancer：a Multi-center, Multi-cohort Phase II Trial

All trans retinoic acid Combined with Toripalimab+Chemotherapy for Locally Advanced inoperable or Metastatic Triple Negative Breast Cancer：a multi-center, multi-cohort phase II trial

Start Date04 Nov 2024

Sponsor / Collaborator

Fudan University

100 Clinical Results associated with Paclitaxel/Cisplatin

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100 Translational Medicine associated with Paclitaxel/Cisplatin

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100 Patents (Medical) associated with Paclitaxel/Cisplatin

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223

Literatures (Medical) associated with Paclitaxel/Cisplatin

01 Mar 2026·BIOMEDICAL CHROMATOGRAPHY

Integrating Metabolomics and Serum Pharmacochemistry to Reveal Potential Hemostatic Components and Processing Mechanisms of Carbonized Typhae Pollen

Article

Author: Chen, Lei ; He, Haotian ; Meng, Jiang ; Sun, Fei ; Li, Jiaqi

ABSTRACT:

Typhae Pollen (TP) is a traditional Chinese medicine used to resolve blood stasis and stop bleeding. Its carbonized form (CTP) shows enhanced hemostatic effects, though the underlying mechanisms remain unclear. This study combined metabolomics and serum pharmacochemistry to identify active components and elucidate CTP's superior efficacy. An abnormal uterine bleeding rat model was induced by exogenous estrogen and treated with TP or CTP extracts. CTP more effectively regulated coagulation parameters, promoted endometrial repair, and reduced inflammation compared to TP. Metabolomics revealed 43 differential metabolites between control and model groups; CTP modulated 31, while TP affected 21. Both influenced arachidonic acid, glycerophospholipid, and linoleic acid metabolism, but only CTP enhanced tryptophan metabolism. Serum analysis detected 24 prototype compounds and 29 metabolites for TP, and 19 and 25 for CTP. Pearson correlation identified 5 and 12 potential hemostatic constituents, respectively. This integrated approach clarifies the material basis for CTP's enhanced activity and advances understanding of carbonized TCMs.

01 Feb 2026·PHYTOMEDICINE

Carbonized Typhae Pollen coordinates VEGF-dependent hemostatic and vascular protective pathways in blood stasis syndrome

Article

Author: Gao, Mingliang ; Zhang, Haotian ; Yao, Weifeng ; Jiang, Xuan ; Jiang, Lejing ; Xu, Yuanyuan ; Yan, Hui ; Cao, Yudan ; Zhang, Li ; Cheng, Fangfang ; Wei, Kaifeng ; Chen, Peidong ; Zhang, Xingyong

BACKGROUND:

Carbonized Typhae Pollen (CTP) is a class of herbs that resolves blood stasis and stops bleeding. Blood stasis syndrome (BSS) is a pathological state associated with blood circulation disorders and vascular injury, which contributes to the development of cardiovascular diseases. The metabolic microenvironment of endothelial cells (ECs) plays a pivotal role in maintaining vascular homeostasis and is highly sensitive to pathological disturbances. CTP positively enhances the hemostatic phase via the vascular endothelial growth factor (VEGF)/phospholipase C gamma 1 (PLCγ1)/Ca²⁺/cyclooxygenase 2 (COX-2) pathway. Excessive hemostasis may increase the risk of vascular disease. Therefore, the dual pharmacological effect of CTP in achieving "stop bleeding without leaving stasis" implies the involvement of additional regulatory pathways that contribute to vascular protection.

PURPOSE:

This study aims to elucidate the protective mechanisms of CTP against BSS-induced circulatory disorders and vascular injury.

METHODS:

Models of BSS rats, zebrafish thrombosis model, and hypoxia-induced ECs model were used to evaluate vascular protection. Bioinformatics, metabolomic analyses, and molecular biology studies were integrated to investigate underlying mechanisms.

RESULTS:

Treatment with CTP promoted blood circulation, and ameliorated thrombosis in zebrafish. Furthermore, CTP markedly attenuated hypoxia and inflammation caused by blood stasis and facilitated vascular remodeling. Bioinformatics and metabolomic analyses suggested that VEGF and downstream arginine metabolism were key pathways. CTP enhanced vascular protection and promoted remodeling through the VEGF/PI3K/AKT signalling pathway, thereby facilitating vascular repair following injury.

CONCLUSIONS:

CTP mediated haemostasis through the VEGF/PLCγ1/Ca²⁺/COX-2 pathway while improving vascular function following haemostasis via the VEGF/PI3K/AKT pathway. These pathways function independently yet remain interconnected, jointly contributing to the vascular homeostasis.

01 Feb 2026·PROTEIN AND PEPTIDE LETTERS

The Glycine-Proline-Hydroxyproline Tripeptide Reduces Cell Death Caused by Glycative Stress

Article

Author: Sakai-Sakasai, Akiko ; Takeuchi, Masayoshi ; Numata, Noriaki ; Yamamoto, Shoko ; Matsumoto, Yo ; Yanbe, Fumihiro

Introduction::

Long-term intake of Collagen Tripeptide (CTP), which is rich in Glycine- X-Y sequences, improves blood vessel elasticity and reduces the serum levels of cytotoxic glyceraldehyde (GA)-derived Advanced Glycation End-Products (AGEs), also known as Toxic AGEs (TAGE). Therefore, the anti-glycation effect of CTP may be one of the mechanisms contributing to its ability to improve vascular elasticity. This study aims to investigate the antiglycation effects of the tripeptide, glycine-proline-hydroxyproline (Gly-Pro-Hyp; GPHyp), the main component of CTP, using in vitro GA glycation models and comparing its metabolite sequences.

Methods::

Cell viability and mRNA expression were measured in GA-treated HepG2 cells with or without the addition of GPHyp. The half-maximal inhibitory concentration (IC50) of GPHyp for inhibiting TAGE formation and for inhibiting lysozyme glycation crosslinking was evaluated.

Results::

Only GPHyp significantly suppressed cell death and interleukin-8 (IL-8) mRNA expression in GA-treated cells. The IC50 for TAGE production and inhibitory effect on lysozyme crosslinking demonstrated that GPHyp exhibited stronger anti-glycation effects than its metabolite amino acids and peptides. The addition of GPHyp also resulted in increased GA consumption. Analysis of the changes in GA concentrations during the reaction revealed that the addition of GPHyp significantly reduced GA levels within the first hour.

Discussion::

These results suggest that GPHyp possesses potent GA-scavenging activity and inhibits TAGE production, contributing to the CTP-mediated reduction in serum TAGE levels and to improvements in vascular elasticity.

Conclusion::

The anti-glycation effect of GPHyp may support a healthy lifestyle and warrant further investigation.

100 Deals associated with Paclitaxel/Cisplatin

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