Author: Santos, Abner Pais dos ; Gonçalves‐Vidigal, Maria Celeste ; Reche, Deivid Lincoln ; Lacanallo, Giselly Figueiredo ; Santos, Alessandro A. Brito dos ; Vidigal Filho, Pedro Soares ; Vaz Bisneta, Mariana

AbstractThe increase in world population linked to climate change leads to the need to develop more productive and more adapted cultivars of food species. Quantitative trait loci (QTLs) mapping is a useful tool although, interaction between genotype and the environment is still a challenge. In this study, we sought to identify QTL related to grain yield and the production components in common beans (Phaseolus vulgaris L.) supported by QTL environment interaction. Two hundred eight recombinant inbred lines obtained from the Awauna UEM IPR88 Uirapuru common bean cross were evaluated in 2017, 2018, and 2019 in field conditions under a 15 × 15 triple lattice experimental design. QTL mapping was estimated using genotypic means and a genetic linkage map with 288 single nucleotide polymorphism markers. Five QTLs associated with plant height (PH), number of pods per plant (NPP), first pod height (FPH), 100‐seed weight (SW), and grain yield per plant (GYP) were identified on chromosomes Pv01, Pv04, Pv08, and Pv10. Interestingly, three of these QTLs were co‐localized for more than one trait, where the QTL for PH, NPP, and GYP co‐locate on Pv01, the QTL for PH and FPH co‐locate on Pv04, and the QTL for NPP and SW co‐locate on Pv08. In turn, on Pv10, two distinct QTLs were found for SW. The identification of these QTLs stands out in Brazil since relatively little research is directed at this economically important commercial group. It is noteworthy that the molecular markers found linked to the QTLs must later be validated to be used in a multi‐trait marker‐assisted selection.

01 May 2003·The Journal of Pharmacology and Experimental TherapeuticsQ3 · MEDICINE

Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor

Q3 · MEDICINE

Article

Author: Wettlaufer, David G. ; Conn, P. Michael ; Goulet, Mark ; Greer, Jonathan ; Janovick, Jo Ann ; Bush, Eugene

We expressed a test system of wild-type (WT) rat (r) and human (h) gonadotropin-releasing hormone (GnRH) receptors (GnRHRs), including naturally occurring (13) and manufactured (five) "loss-of-function" mutants of the GnRHR. These were used to assess the ability of different GnRH peptidomimetics to rescue defective GnRHR mutants and determine their effect on the level of membrane expression of the WT receptors. Among the manufactured mutants were the shortest rGnRHR C-terminal truncation mutant that resulted in receptor loss-of-function (des(325-327)-rGnRHR), two nonfunctional deletion mutants (des(237-241)-rGnRHR and des(260-265)-rGnRHR), two nonfunctional Cys mutants (C(229)A-rGnRHR and C(278)A-rGnRHR); the naturally occurring mutants included all 13 full-length GnRHR point mutations reported to date that result in full or partial human hypogonadotropic hypogonadism. The 10 peptidomimetics assessed as potential rescue molecules ("pharmacoperones") are from three differing chemical pedigrees (indoles, quinolones, and erythromycin-derived macrolides) and were originally developed as GnRH peptidomimetic antagonists. These structures were selected for this study because of their predicted ability to permeate the cell membrane and interact with a defined affinity with the GnRH receptor. All peptidomimetics studied with an IC(50) value (for hGnRHR)

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