Last update 31 May 2025

WF-2421

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FR-900280
Target
AKR1B1 x Oxidoreductases
Action
inhibitors
Mechanism
AKR1B1 inhibitors(Aldose reductase inhibitors), Oxidoreductases inhibitors
Therapeutic Areas
Endocrinology and Metabolic Disease
Active Indication-
Inactive Indication
Diabetes Complications
Originator Organization
Astellas Pharma, Inc.Astellas Pharma, Inc.
Active Organization-
Inactive Organization
Astellas Pharma, Inc.Astellas Pharma, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC19H20N2NaO8
InChIKeyJAPMHCAVRINUMT-UHFFFAOYSA-N
CAS Registry128524-51-6

Related

100 Clinical Results associated with WF-2421
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100 Translational Medicine associated with WF-2421
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100 Patents (Medical) associated with WF-2421
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1
Literatures (Medical) associated with WF-2421
01 Jan 1991The Journal of antibioticsQ4 · MEDICINE
WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea.
Q4 · MEDICINE
100 Deals associated with WF-2421
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes ComplicationsPreclinical-
Astellas Pharma, Inc.Astellas Pharma, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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