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Last update 08 May 2025

Sodium Chromate CR-51

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Chromitope Sodium

Target-

Action-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Bracco Diagnostics, Inc.

Active Organization-

Inactive Organization

Bracco Diagnostics, Inc.

License Organization-

Drug Highest PhaseWithdrawn

First Approval Date

United States (27 Dec 1971)

Regulation-

Structure/Sequence

Molecular FormulaCrH2Na2O4

InChIKeyLGPNQOUWASOJQE-PJWPDVOUSA-L

CAS Registry10039-53-9

100 Clinical Results associated with Sodium Chromate CR-51

100 Translational Medicine associated with Sodium Chromate CR-51

100 Patents (Medical) associated with Sodium Chromate CR-51

Literatures (Medical) associated with Sodium Chromate CR-51

01 Jun 2005·Nuclear Medicine CommunicationsQ4 · MEDICINE

Long-lived radiopharmaceuticals: Dispensing from multidose vials

Q4 · MEDICINE

Article

Author: Hilditch, Thomas E. ; Elliott, Alex T. ; Murray, Tom

We report the use of broth simulation as a means of validating the practice of sub-dispensing from stock vials of long-lived sterile radiopharmaceuticals. 'Matched' vials of nutrient broth accompanied the stock vials of long-lived sterile radiopharmaceuticals during their time in use and were subject to the same handling and storage procedures. At the end of the life of each radiopharmaceutical stock vial, the matching broth residue was sent for incubation and reporting. The results to date have yielded no reports of microbial contamination in any of the simulated broths (0 in 256).

01 Jan 2003·Czechoslovak Journal of Physics

A novel radiotracer method to study the formation of surface adlayers in the course of Cr(VI) reduction of a gold electrode

Author: K. Varga ; I. Szalóki ; L. Gáncs ; R. Marczona

In this paper, we report some new findings obtained by in situ radiotracer and voltammetric studies of the simultaneous adsorption of HSO₄^-/SO₄^2- ions labeled with ³⁵S, and Cr-containing species labeled with ⁵¹Cr on a gold electrode in the course of dichromate reduction in 1 mol dm^-3 ClO₄^- supporting electrolyte at various pH values (pH = 0 and pH = 2.0).Special attention is paid to show a modified version of the in situ radiotracer "foil" method, as well as to present a detection and calculation procedure elaborated for the quant. evaluation of the surface excess of radiolabeled Cr species via measurement of the intensity of low energy x-rays (E = 4.90 keV) emitted by ⁵¹Cr.From our exptl. results it can be stated that: (i) the electroreduction of Cr(VI) particles presumably proceeds via a ce (chem.-electron-transfer) mechanism to yield a gold surface covered with intermediate surface adlayer containing Cr(VI) species and added anions (HSO₄^-/SO₄^2-, ClO₄^-); (ii) the extent and mechanism of adlayer formation are affected by the solution pH values; (iii) the maximum surface excess of Cr-containing species (Γ_pH=0 = 1.2 × 10^-9 mol cm^-2; Γ_pH=2.0 = 1.6 × 10^-9 mol cm^-2), as well as the molar ratio between the Cr species and HSO₄^-/SO₄^2- ions (m _pH=0 ≈ 6 at E = 0.8 V; m _pH=2.0 ≈ 2 at E = 0.05 V) attest that the coverage of the gold surface with intermediate complexes does not exceed one monolayer.

01 Apr 2001·Nuclear Medicine and BiologyQ4 · MEDICINE

A simple and inexpensive preparation of [51Cr]-MAA particles

Q4 · MEDICINE

Article

Author: Chatterton, B. E. ; Brundell, S. ; Tsopelas, C.

The feasibility of preparing [(51)Cr]-MAA was investigated using an MAA cold kit and commercially available sodium [(51)Cr]chromate solutions. Of different conditions tested, the best required an addition of a low level of sodium dithionite to achieve a radiolabeling efficiency of 44%. The product was purified by centrifugation to give [(51)Cr]-MAA with 99 +/- 1% radiochemical purity (RCP) comprised of >94% radioactive particles >10 microm, and resulted in a rat biodistribution with >80% in the lungs. [(51)Cr]-MAA is inexpensive, easily and conveniently prepared by this procedure.

100 Deals associated with Sodium Chromate CR-51

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB09380

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