Evaluation of the tolerability, safety and preliminary efficacy of H021 tablets in patients with ulcerative colitis: a multicenter, open, single-arm phase Ic clinical trial

Start Date16 Apr 2025

Sponsor / Collaborator-

ChiCTR2500097602

/ SuspendedPhase 1IIT

A Randomized, Double-Blind, Placebo-Controlled Phase Ib Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Multiple Doses of H021 Tablets in Healthy Adult Subjects

Start Date02 Mar 2025

Sponsor / Collaborator

Second Affiliated Hospital of Soochow University

CTR20250561

/ CompletedPhase 1

随机、双盲、安慰剂对照评价H021片多次给药在健康成年受试者中的安全性、耐受性和药代动力学（PK）的Ib期临床研究

[Translation] A randomized, double-blind, placebo-controlled Phase Ib clinical study to evaluate the safety, tolerability and pharmacokinetics (PK) of H021 tablets after multiple administration in healthy adult subjects

1.主要目的：考察健康成年受试者多次口服H021片的安全性和耐受性。 2.次要目的：研究健康成年受试者多次口服H021片的PK特征，为后期临床研究的剂量选择提供依据。

[Translation]

1. Primary purpose: To investigate the safety and tolerability of H021 tablets after multiple oral administration in healthy adult subjects. 2. Secondary purpose: To study the PK characteristics of H021 tablets after multiple oral administration in healthy adult subjects, and to provide a basis for the dose selection in later clinical studies.

Start Date21 Feb 2025

Sponsor / Collaborator

Jiangsu Carephar Pharmaceutical Co., Ltd.

100 Clinical Results associated with H021

100 Translational Medicine associated with H021

100 Patents (Medical) associated with H021

Literatures (Medical) associated with H021

20 Oct 2023·Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

H - 21 ¿Habla Español? Increasing Access to Clinical and Educational Materials for Non-English Speakers.

Article

Author: Caicedo, Mariana Rincon ; Punt, Stephanie E ; Schuttler, Jessica ; Gordon, Chandra

OBJECTIVEEffective communication is an essential factor in successful health care delivery. However, Hispanic-Americans, many of whom are non-English speakers, face disparities related to a lack of multilingual providers and resources in their preferred language. The goal of this quality improvement project was to increase access to clinical and educational materials for non-English speakers at an outpatient pediatric clinic.METHODA survey assessing the availability of bi- or multilingual providers and staff as well as Spanish materials utilized by providers was disseminated to all staff working at the Pediatrics Department, including the Division of Developmental/Behavioral Sciences, of an academic medical center. Participants uploaded resources they use to assist in the development of a departmental repository of Spanish materials.RESULTSData was collected November 2022-January 2023. Sixty-five participants completed the survey with 28% speaking Spanish, and 23% reporting they provide health care services in Spanish. Forty-six different kinds of resources were identified, and eight were uploaded and compiled into a repository with the goal of being distributed across the department to be used by providers and staff.CONCLUSIONSAlthough valuable work has been done to develop culturally-appropriate materials in Spanish for health care use, the availability and use of these resources appears to be limited. Building an infrastructure for sharing these materials department-wide, and broader within healthcare systems is essential. Further research is needed to understand the cultural appropriateness of health-related materials translated into Spanish, and in developing guidelines for the translation and adaptation of materials for a growing culturally-diverse patient population.

01 Oct 2023·Research in veterinary science

Teat-apex colonizer Bacillus from healthy cows antagonizes mastitis-causing Staphylococcus aureus biofilms.

Article

Author: De Lillo, María Florencia ; Bohl, Luciana Paola ; Isaac, Paula ; Calvinho, Luis Fernando ; Rodríguez Berdini, Lucía ; Porporatto, Carina ; Orellano, María Soledad ; Breser, María Laura ; Romero, Cintia Mariana

Staphylococcus aureus is the most frequent causal agent of bovine mastitis, which is largely responsible for milk production losses worldwide. The pathogen's ability to form stable biofilms facilitates intramammary colonization and may explain disease persistence. This virulence factor is also highly influential in the development of chronic intramammary infections refractory to antimicrobial therapy, which is why novel therapies that can tackle multiple targets are necessary. Since udder microbiota have important implications in mastitis pathogenesis, they offer opportunities to develop alternative prophylactic and therapeutic strategies. Here, we observed that a Bacillus strain from the teat apex of lactating cows was associated to reduce colonization by S. aureus. The strain, identified as Bacillus sp. H21, was able to antagonize in-formation or mature S. aureus biofilms associated to intramammary infections without affecting cell viability. When exploring the metabolite responsible for this activity, we found that a widespread class of Bacillus exopolysaccharide, levan, eliminated the pathogenic biofilm under evaluated conditions. Moreover, levan had no cytotoxic effects on bovine cellular lines at the biologically active concentration range, which demonstrates its potential for pathogen control. Our results indicate that commensal Bacillus may counteract S. aureus-induced mastitis, and could therefore be used in novel biotechnological strategies to prevent and/or treat this disease.

01 Jan 2000·Inorganic ChemistryQ2 · CHEMISTRY

Neocuproine-Extended Porphyrin Coordination Complexes. 2. Spectroscopic Properties of the Metalloporphyrin Derivatives and Investigations into the HOMO Ordering

Q2 · CHEMISTRY

Article

Author: Vannelli, Tommaso A. ; Karpishin, Timothy B.

The synthesis of a porphyrin compound, 1, containing a 2,9-dimethyl-1,10-phenanthroline moiety that is fused at the beta-pyrrole positions is reported. The absorption spectra of the free-base, copper(II), and zinc(II) derivatives have been studied. On the basis of absorption band intensities, the HOMO of the free base (H21) and its copper and zinc complexes (Cu1 and Zn1) was determined to be of a1u symmetry. Relative to H21, compounds Cul and Znl show enhanced spectral changes upon external metal ion binding. Although the HOMO is the same in all three compounds, the energy gap between the two highest occupied orbitals is greater for Cu1 and Zn1 than it is for the free-base compound. Several metal ions (Ni2+, Cu+, Cu2+, Zn2+, Li+) were examined in their binding to the phenanthrolinic group by measuring the resulting changes in the absorption spectra. It is shown that the observed changes in the absorption spectra are insensitive to the nature of the metal ion coordinated by the phenanthroline moiety. Significant differences in the absorption and emission spectra between Zn1 and [Zn(Zn1)2]2+ clearly demonstrate that the porphyrin pi-system is strongly affected by the binding of metal ions at the fused phenanthrolinic moiety.

100 Deals associated with H021

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Indication	Highest Phase	Country/Location	Organization	Date
Colitis, Ulcerative	Phase 1	Australia	Jiangsu Carephar Pharmaceutical Co., Ltd.	17 Sep 2024

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