Last update 21 Dec 2024
Lidocaine/Sodium bicarbonate
Last update 21 Dec 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms PSD 597, PSD-597 |
Target |
Mechanism SCNA modulators(Sodium channel alpha subunit modulators) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
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Structure
Molecular FormulaC14H22N2O |
InChIKeyNNJVILVZKWQKPM-UHFFFAOYSA-N |
CAS Registry137-58-6 |
View All Structures (2)
Related
7
Clinical Trials associated with Lidocaine/Sodium bicarbonateLidocaine as an ETT Cuff Media in the Immediate Post-operative Cardiac Surgery Patient Population, and Its Effect on Sedation/Analgesia Requirements: a Pilot Study
Comparison of the effect of lidocaine-bicarbonate, lidocaine-dexamethasone and lidocaine alone for digital block in patients with figure injury: a double blind randomized clinical trial
Buffered Lidocaine for Paracervical Block to Decrease Injection Pain During First Trimester Uterine Aspirations
100 Clinical Results associated with Lidocaine/Sodium bicarbonate
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100 Translational Medicine associated with Lidocaine/Sodium bicarbonate
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100 Patents (Medical) associated with Lidocaine/Sodium bicarbonate
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3
Literatures (Medical) associated with Lidocaine/Sodium bicarbonate01 Sep 2017Journal of the American College of Radiology : JACRQ2 · MEDICINE
Impact of Sodium Bicarbonate-Buffered Lidocaine on Patient Pain During Image-Guided Breast Biopsy
Q2 · MEDICINE
Article
Author: Soo, Mary Scott C ; Shelby, Rebecca A ; Vasan, Alison ; Baker, Jay A
PURPOSE:
This randomized, double-blind controlled study evaluated the effectiveness of sodium bicarbonate-buffered lidocaine on reducing pain during imaging-guided breast biopsies.
MATERIALS AND METHODS:
This prospective, HIPAA-compliant study randomly assigned 85 women undergoing ultrasound- or stereotactic-guided core-needle breast biopsies to receive intradermally and intraparenchymally either 1% lidocaine buffered with sodium bicarbonate (9:1 ratio) (bicarbonate study group) or 1% lidocaine alone (control group). Pain was evaluated using a 0-to-10 Likert pain scale during both intradermal and intraparenchymal anesthesia injections and during tissue sampling. Prebiopsy breast pain, anxiety, medical history, demographics, biopsy type, radiologist level of training, breast density, and lesion histology were recorded. Data were analyzed using analysis of variance and analysis of covariance.
RESULTS:
Unadjusted mean pain scores were 1.47 and 2.07 (study and control groups, respectively; P = .15) during intradermal injections, and 1.84 and 2.98 (study and control groups, respectively; P = .03) during intraparenchymal injections. Tissue sampling mean pain scores were .81 and 1.71 (study and control groups, respectively; P = .07). Moderator analyses found (1) among patients with preprocedural pain, those in the bicarbonate group experienced less intradermal injection pain (0.85 ± 1.23) than patients in the control group (2.50 ± 2.09); (2) among patients with fatty or scattered fibroglandular tissue, those in the bicarbonate group (1.35 ± 1.95) experienced less intraparenchymal injection pain than the control group (3.52 ± 3.13); and (3) during ultrasound-guided biopsies, patients in the bicarbonate group experienced less tissue-sampling pain (0.23 ± 0.63) than the control group (1.79 ± 3.05).
CONCLUSIONS:
Overall, buffering lidocaine with sodium bicarbonate significantly reduced pain during intraparenchymal injections, and additional pain reduction was found in certain patient subgroups during intradermal injections, intraparenchymal injections, and tissue sampling.
01 Jan 2015Journal of endodonticsQ2 · MEDICINE
Effect of Sodium Bicarbonate–buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study
Q2 · MEDICINE
Article
Author: Baghaei, Badri ; Saatchi, Masoud ; Noormohammadi, Hamid ; Khademi, Abbasali
INTRODUCTION:
The purpose of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of buffered with nonbuffered 2% lidocaine with 1:80,000 epinephrine solution for inferior alveolar nerve (IAN) block in patients with mandibular posterior teeth experiencing symptomatic irreversible pulpitis.
METHODS:
Eighty adult patients diagnosed with symptomatic irreversible pulpitis of a mandibular posterior tooth were selected. The patients received 2 cartridges of either 2% lidocaine with 1:80,000 epinephrine buffered with 0.18 mL 8.4% sodium bicarbonate or 2% lidocaine with 1:80,000 epinephrine with 0.18 mL sterile distilled water using conventional IAN block injections. Endodontic access preparation was initiated 15 minutes after injection. Lip numbness was required for all the patients. Success was determined as no or mild pain on the basis of Heft-Parker visual analog scale recordings upon access cavity preparation or initial instrumentation. Data were analyzed by the t, Mann-Whitney, and chi-square tests.
RESULTS:
The success rates were 62.5% and 47.5% for buffered and nonbuffered groups, respectively, with no significant differences between the two groups (P = .381).
CONCLUSIONS:
Buffering the 2% lidocaine with 1:80,000 epinephrine with 8.4% sodium bicarbonate did not improve the success of the IAN block in mandibular molars in patients with symptomatic irreversible pulpitis.
01 Apr 2009BJU internationalQ2 · MEDICINE
Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome
Q2 · MEDICINE
Article
Author: Edward L. Davis ; Michael G. Wyllie ; J. Curtis Nickel ; Richard A. Henry ; Soledad Lee ; Robert Moldwin
OBJECTIVE:
To assess the immediate and sustained relief of the symptoms of interstitial cystitis/painful bladder syndrome (IC/PBlS) after a consecutive 5‐day course of treatment with intravesical alkalinized lidocaine (PSD597), and to characterize the pharmacokinetics of single and multiple doses of intravesical PSD597 in a subgroup of patients.
PATIENTS AND METHODS:
In all, 102 adult patients (99 women) with a clinical diagnosis of IC/PBlS were randomized from 19 centres in the USA and Canada to receive a daily intravesical instillation of PSD597 (200 mg lidocaine, alkalinized with a sequential instillation of 8.4% sodium bicarbonate solution, to a final volume of 10 mL) or placebo (double‐blind), for 5 consecutive days. Patients were followed at intervals up to 29 days after the first instillation. Efficacy was assessed by changes in the Global Response Assessment (GRA), Likert scales for bladder pain, urgency and frequency, and validated O’Leary‐Sant IC symptom and problem indices.
RESULTS:
Significantly more patients treated with PSD597 rated their overall bladder symptoms as moderately or markedly improved on the GRA scale 3 days after completing the 5‐day course of treatment (30% and 9.6%, respectively, for patients treated with PSD597 and placebo; P = 0.012). The treatment effects were also maintained beyond the end of treatment and are further supported by the secondary endpoints, including symptom and problem indices. The peak serum lidocaine concentration during the study was <2 µg/mL, and well below the toxic level (>5 µg/mL).
CONCLUSION:
This preliminary study showed that PSD597 was effective for providing sustained amelioration of symptoms of IC/PBlS beyond the acute treatment phase. The drug was safe, well tolerated and devoid of the systemic side‐effects often experienced with oral drug administration. Long‐term studies are needed to determine the optimum regimen to maintain this favourable treatment effect.
100 Deals associated with Lidocaine/Sodium bicarbonate
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Cystitis, Interstitial | Phase 2 | - | - |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 4 | 98 | (Standard Paracervical Block) | hslrukkgbm(teseqqppqy) = fpsncnhzvo eqwsydwdbr (wnxpquzeoe, vucptfpfos - ihxamwooef) View more | - | 15 May 2020 | ||
(Buffered Lidocaine Paracervical Block) | hslrukkgbm(teseqqppqy) = mdyonhrbxw eqwsydwdbr (wnxpquzeoe, ahnzcpckgo - lzvlvqpwif) View more |
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