cf. C. A. 23, 3470.New thiazoles containing aromatic groups in positions 2 and 4 of the thiazole cycle have been prepared as follows: 2-[p-Methoxyphenyl], from bromoacetal and thioanisamide (I), b6, 156-8°, m. 12-5° (110 salt, m. 167-9°;73% yield); p-[hydroxyphenyl], by demethylation with 48% HBr, m. 163-5° (HCl salt, crystallizes with 0.5 mol.EtOH, m. 178-80°); 2-[p-methoxyphenyl]-4-methyl, from ClCH2Ac and I, b7 168°, m. 57° (HCl salt, crystals with 0.5 mol.EtOH, m. 130-2°); 90% yield; p-HO derivative m. 220-1° (HCl salt, m. 250-3°; 2-[p-methoxyphenyl]-4-[3,4-dihydroxyphenyl], crystals with 2 mols.H2O, m. 154-5° (HCl salt, m. 206-8°; p-HO derivative, crystals with 2 mols.H2O, m. 212-3°; 2-[3,4-dihydroxyphenyl]-4-[3,4-dihydroxyphenyl], crystals with 1 mol.H2O, m. 207°, in 80% yield from chloroacetopyrocutechol and 3,4-dihydroxythiobenzamide, m. 153-4°; with bromoacetal there results the 2-[3,4-dihydroxyphenyl] derivative, m. 181° (HCl salt, m. 215-8°); ClCH2Ac gives the 2-[3,4-dihydroxyphenyl]-4-methyl derivative, whose HCl salt m. 250°; bromoacetal and piperonylthioamide, m. 180° (81% yield), give the 2-[3,4-methylenedioxyphenyl] derivative, m. 84-5°; (HCl salt, m. 216°); 2-[3,4-methylenedioxyphenyl]-4-methyl, m. 94-5° (91% yield) (HCl salt, crystals with 1 mol.EtOH), the 4-[3,4-dihydroxyphenyl]-2-[3,4-methylenedioxyphenyl] derivative, crystals with 2 H2O, m. 135°, or anhyd, m. 185° (99% yield) (HCl salt, m. 212-6°).The pharmacol. behavior of these compounds is briefly discussed.