Effects of dietary supplementation with olive cake enriched in polyphenols on growth, rumen fermentation, and metabolic status of finishing Limousine bulls

Author: Ferronato, G. ; Amato, A. ; Cavallo, C. ; Trevisi, E. ; Chiofalo, V. ; Llobat, L. ; Liotta, L. ; Lopreiato, V.

The integration of olive cake in ruminants diet can represent a path to reduce environmental impact and cost-associated disposal.Finishing Limousine bulls supplemented with olive cake showed higher rumen propionate and heptanoate and lower acetate, isobutyrate, and isovaleriate content than control bulls.The supplementation of olive cake influenced metabolic, liver, and antioxidant markers in finishing Limousine bulls, suggesting it could have not well understood effects on their health status.

01 Sep 2025·Neural Regeneration Research

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

Article

Author: Shao, Qianqian ; Ji, Xunming ; Gu, Yakun ; Wang, Yi ; Guo, Mengyuan ; Liu, Jia ; Ma, Wei ; Guan, Yuying ; Li, Yuning

01 Sep 2025·Biomaterials

Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy

Article

Author: Li, Chao ; Ding, Qihang ; Lu, Zhiyun ; Gong, Ping ; Jia, Jia ; Yang, Xing ; Kim, Jong Seung ; Liu, Yu ; Zhou, Hui ; Xiang, Chunbai ; Jiang, Ting ; Xiang, Jingjing ; Wang, Yue

Small molecule-based multifunctional optical diagnostic materials have garnered considerable interest due to their highly customizable structures, tunable excited-state properties, and remarkable biocompatibility. We herein report the synthesis of a multifaceted photosensitizer, PPQ-CTPA, which exhibits exceptional efficacy in generating Type I reactive oxygen species (ROS) and thermal energy under near-infrared-II (NIR-II, >1000 nm) laser excitation at 1064 nm, thereby combining photodynamic therapy (PDT) and photothermal therapy (PTT) functionalities. To enhance therapeutic efficacy, we engineered lonidamine (LND) by conjugating it with triphenylphosphonium (TPP) cations, producing LND-TPP. This compound inhibits mitochondrial glycolysis and downregulates heat shock protein 90 (HSP 90) levels in a breast cancer mouse model, potentiating both PDT and PTT. For in vivo applications, PPQ-CTPA and LND-TPP are encapsulated within the amphiphilic polymer DSPE-SS-PEG to obtain PPQ-CTPAL NPs. In breast cancer cell lines, PPQ-CTPAL NPs are decomposed by cellular GSH, simultaneously releasing the dual-functioning photosensitizer PPQ-CTPL and the mitochondria-disrupting agent LND-TPP. Upon 1064 nm laser irradiation, we found that tumor growth in breast cancer mice is effectively restrained by PPQ-CTPAL NPs. This work highlights the synergistic integration of PDT, PTT, and chemotherapy facilitated by NIR-II fluorescence, photoacoustic, and photothermal imaging under 1064 nm irradiation, underscoring the clinical potential of multifunctional phototherapeutic agents.

100 Deals associated with Bilirubin

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	China	Zhengzhou University	01 Nov 2021

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