Last update 20 Apr 2026

XM146-SN38

Overview

Basic Info

Drug Type
Peptide drug conjugates
Synonyms
PDL1-targeting polypeptide-MPA-SN38 conjugate, XM146 01, XM14601
Target
PDL1 x Top I
Action
inhibitors
Mechanism
PDL1 inhibitors(Programmed death-ligand 1 inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease
Active Indication
Pancreatic Ductal Adenocarcinoma
Inactive Indication-
Originator Organization
Excellamol, Inc.Excellamol, Inc.
Active Organization
Excellamol, Inc.Excellamol, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
RegulationOrphan Drug (United States)

Structure/Sequence

Molecular FormulaC22H20N2O5
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS Registry86639-52-3
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Related

100 Clinical Results associated with XM146-SN38
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100 Translational Medicine associated with XM146-SN38
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100 Patents (Medical) associated with XM146-SN38
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100 Deals associated with XM146-SN38
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic Ductal AdenocarcinomaPreclinical
South Korea
Excellamol, Inc.Excellamol, Inc.
17 Jun 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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