Two neutral polysaccharides named POP-1 and PCP-1 were purified from Polygonatum odoratum and P. cyrtonema, respectively. Results showed that both of them were composed of fructose and glucose, and the average molecular weights of them were about 5 kDa. FT-IR, 1D- and 2D-NMR analyses revealed that both POP-1 and PCP-1 contained a (2→1)-linked β-d-fructofuranose (Fruf) backbone and (2→6)-linked β-d-Fruf side chains with an internal α-d-glucopyranose (Glcp) in neokestose form. The difference between these two purified polysaccharides were that PCP-1 possessed of an acetyl group attached at O-3 of α-d-Glcp residue. In addition, PCP-1 exhibited a little better immune stimulating activity than POP-1 on cell viability and IL-6 production of RAW 264.7 macrophages. These results indicated that the acetyl group might affect the immunoregulatory activity and PCP-1 have more potential to be explored as an immunomodulatory agent.

26 Sep 2018·ACS Applied Materials & InterfacesQ2 · MATERIALS SCIENCE

Selective Adsorption and Separation of Xylene Isomers and Benzene/Cyclohexane with Microporous Organic Polymers POP-1

Q2 · MATERIALS SCIENCE

Article

Author: Chen, Tingting ; Chen, Qibin ; Liu, Honglai ; Tan, Huiling

The separation of chemical substances with analogous chemical structures and physical properties remains a great challenge. In this work, triptycene-like microporous organic polymers (MOPs), POP-1, was synthesized via choosing 1,4-dimethoxybenzene (DMB) and triptycene as external cross-linkers and building blocks, respectively, and POP-1 was employed to separate xylene isomers and benzene (Bz)/cyclohexane (Cy). Results show that POP-1 has a higher uptake for m-xylene (0.29 g/g) and Bz (1.02 g/g); more intriguingly, their complete separation can be realized within 0.6 min using a column packed with POP-1. The interaction between POP-1 networks and adsorbates was also investigated using theoretical (density functional theory together with noncovalent interaction analysis) and experimental (inverse gas chromatography) approaches. Especially, both results present a good agreement, that is, weak interactions such as CH/π interactions play a dominant role in defining the separation performance of POP-1 for xylene isomers and Bz/Cy mixtures. Our findings suggest that MOPs may open up a new route for separating the chemicals that are similar in structure and size.

01 Jul 2017·Science Bulletin

Construction of porous covalent organic polymer as photocatalysts for RhB degradation under visible light

Article

Author: Xing, Lingbao ; Su, Zhongmin ; Lin, Hongtao ; Zhou, Ziyan ; Liu, Pingxiao ; Wang, Haining

In the present work, a novel porous, and chemically stable amine-based covalent organic polymer (POP-1) was designed and synthesized under solvothermal conditions. The porosity, crystallinity, chemical stability, electrochemical properties, and diffuse reflectance of POP-1 were investigated via N₂ sorption experiment, power X-ray diffraction, thermogravimetric analysis, cyclic voltammetry, and ultraviolet visible near infrared spectrometry, respectively. POP-1 exhibits good chemical stability in both acidic and alkaline aqueous solutions, as well as in organic solvents. Undoped POP-1 can be directly used as a photocatalyst for rhodamine B irradiation degradation under light-emitting diode and natural light. The E_a of POP-1 for RhB degradation is 82.37kJ/mol. Furthermore, POP-1 can be reused as a catalyst in RhB degradation without degraded catalytic activity.

100 Deals associated with POP-1

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Solid tumor	Preclinical	AU	Propanc Pty Ltd.	30 Jan 2022
Neoplasms	Preclinical	AU	Propanc Biopharma, Inc.	-
Ovarian Cancer	Preclinical	ES	Propanc Biopharma, Inc.	-
Pancreatic Cancer	Preclinical	ES	Propanc Biopharma, Inc.	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

POP-1

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation