Delving into the Latest Updates on STA-013 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

EPHB1 x EPHB2 x EphB4

Action

antagonists

Mechanism

EPHB1 antagonists(EPH receptor B1 antagonists), EPHB2 antagonists(EPH receptor B2 antagonists), EphB4 antagonists(Ephrin type-B receptor 4 antagonists)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Metabolic DiseasesObesity

Inactive Indication-

Originator Organization

Texas Tech University Health Sciences Center

Active Organization

Texas Tech University Health Sciences Center

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Fifteen (15) backyard farms were investigated to determine the antimicrobial susceptibility and invasion ability of S. aureus isolates from cows with subclinical mastitis in México. A total of 106 cows were sampled and 31 S. aureus isolates were recovered. S. aureus isolates were resistant to penicillin class antibiotics and susceptible to gentamicin and cetyltrimethylammonium bromide. STA9 and STA13 isolates were resistant to erythromycin (MIC > 25 microg/ml) and lincomycin (STA13, MIC > 25 microg/ml; STA9, MIC > 100 microg/ml). STA9 isolate harbors the erm(B) and msr(A) genes, whereas STA13 isolate harbors the erm(C) gene. STA9 and STA13 isolates contains the lnu(A) gene. Only 5 isolates (STA11, STA13, STA14, STA15 and STA21) were able to internalize in bovine mammary epithelial cells. These results indicate that S. aureus isolates from dairy backyard farms showed differences in the antimicrobial susceptibility patterns and invasion ability in bovine mammary epithelial cells. This kind of evaluations should be performed in different dairy regions, since resistance patterns and isolate diversity vary on a per-region basis.

100 Deals associated with STA-013

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Metabolic Diseases	Preclinical	United States	Texas Tech University Health Sciences Center	17 Mar 2024
Obesity	Preclinical	United States	Texas Tech University Health Sciences Center	17 Mar 2024