The authors studied the effects of myelopeptides (MP) 5 and 6 on the functional activity of peripheral blood lymphocytes in the blast-transformation reaction induced by different concentrations of phytohemagglutinin (PHA).Tetrapeptide MP-6 proved to have the opposite effect on PHA-stimulated and non-stimulated peripheral blood lymphocytes.In addition, the MP-6 effect depended on its own concentration and on the mitogen concentration in the cell culture.Myelopeptide MP-5 proved to have no effect on lymphocyte functional activity.Results suggest an important role played by individual myelopeptides, including MP-6, in the regulation of functional activity of peripheral blood lymphocytes.

01 Jan 2002·Vestnik khirurgii imeni I. I. Grekova

[Lymphotropic immune correction with myelopid in the postoperative period in patients with cancer of the colon and rectum].

Article

Author: Cherkasov, V A ; Shilova, N A ; Kevorkov, N N ; Kataev, V P ; Shilov, Iu I

An analysis of surgical treatment of 142 patients with cancer of the colon and rectum included 32 emergency cases and 110 scheduled operations. Standard surgical methods only were used in 94 patients, the lymphotropic immunocorrection with myelopidum in the postoperative period was made in 48 patients. The use of lymphotropic immunocorrection was shown to considerably improve the immunological parameters and to decrease postoperative lethality.

01 Jul 1995·Allergy and Asthma Proceedings

Myelopeptides: New Immunoregulatory Peptides

Review

Author: Petrov, R

Bone marrow cells of various animal species and humans produce a group of bioregulatory peptides called myelopeptides (MPs). MPs have been isolated and purified, and their physico-chemical properties have been investigated. MPs have a wide spectrum of functional activities: immunoregulatory, differentiating, and opiate-like. A new immunocorrective drug, Myelopidum, which is used effectively in clinical practice for treating diseases accompanied by immunodeficiency, has been created on the basis of MPs. Administration of Myelopidum after surgery prevents 50% to 70% of postsurgical complications, particularly postsurgery pneumonia, and also normalizes the number and balance of T-helper cells, T-suppressor cells, and B-lymphocytes in patients with chronic pulmonary diseases, resulting in a beneficial clinical effect, including a significant prolongation of remission periods. Myelopidum is also used in veterinary medicine for prophylaxis and treatment of pneumonia and enteritis in newborn and young animals. The primary structure of several myelopeptides is established. The functional activities of two, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), are being investigated.

100 Deals associated with Myelopidum

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Indication	Country/Location	Organization	Date
Immunologic Deficiency Syndromes	RU	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry	01 Feb 1995

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