Delving into the Latest Updates on VSV-SARS2(+G) with Synapse

Overview

Basic Info

Drug Type

Prophylactic vaccine

Synonyms-

Target

SARS-CoV-2 S protein

Mechanism

SARS-CoV-2 S protein inhibitors(Coronavirus spike glycoprotein inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Coronavirus Infections

Inactive Indication-

Originator Organization

Vyriad, Inc.Startup

Active Organization

Vyriad, Inc.Startup

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Author: Packiriswamy, Nandakumar ; Muñoz-Alía, Miguel Á ; Narjari, Riya ; Zhang, Lianwen ; Recker, Jordan ; Haselton, Michelle ; Sevola, Kara ; Suksanpaisan, Lukkana ; Russell, Luke ; Sakuma, Toshie ; Graham, Melanie L ; Ziegler, Christopher ; Lee, Rachael M ; Balakrishnan, Baskar ; Russell, Stephen J ; Reiter, Samantha ; Gnanadurai, Clement ; Petro, Christopher D ; Waniger, Scott ; Vandergaast, Rianna ; Tesfay, Mulu ; Kyratsous, Christos A ; Janecek, Jody L ; Carey, Timothy ; Lech, Patrycja ; Krotova, Karina ; Baum, Alina ; Peng, Kah-Whye ; Ramachandran, Sabarinathan ; Lathrum, Chase

An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.

100 Deals associated with VSV-SARS2(+G)

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