While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results.
No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.

Start Date24 Jan 2020

Sponsor / Collaborator

Mansoura University

NCT04462588

/ CompletedNot ApplicableIIT

Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases

After appendectomy was first described by Mcburney in 1889, it has been the most practiced emergency surgery in the world with the lifetime incidence of acute appendicitis being 5%-25%. Most cases are uncomplicated cases without any complications and perforation (20%-30%). Although appendectomy is still a curative therapy, medical treatment has come to the fore in uncomplicated cases after improvements in imaging methods for diagnosing acute appendicitis and especially the developments in antibiotherapy.
Medical treatment for acute appendicitis is, in fact, not a new condition. Practicing the option of elective surgery following intravenous antibiotherapy for plastron appendicitis that is among the complicated acute appendicitis has lead to further consideration of medical treatment. A number of studies conducted for this purpose suggest that conservative treatment in uncomplicated acute appendicitis may be a first-line treatment. Medical treatment of the uncomplicated acute appendicitis prevents negative appendectomies, which indicates that surgical removal of non-inflamed appendix ranging from 6% to 20%. In addition to preventing unnecessary organ loss, it ensures eliminating postoperative complications such as intestinal obstruction and wound site complications due to surgery.
Immature granulocytes (IG) are monitored in peripheral blood as immature polymorphonuclear cells because of the activation of bone marrow. Although their counts can be determined through direct inspection, they can be provided with automated systems within complete blood count parameters as well as technological developments. The increase in their number specifically suggests the activation of the bone marrow and can provide information about the infectious process before leukocytosis is observed.
This study aimed to determine the importance of IG count and percentage to evaluate the role of medical treatment and control its success in cases of uncomplicated acute appendicitis.

Start Date01 Jun 2019

Sponsor / Collaborator

Kahramanmaras Sütçü Imam Üniversitesi

CTR20170435

/ CompletedPhase 3

MK-7625A联合甲硝唑与美罗培南相比治疗复杂性腹腔感染的III期、多中心、双盲、随机、活性药物对照的临床研究

[Translation] A phase III, multicenter, double-blind, randomized, active-controlled clinical study of MK-7625A combined with metronidazole versus meropenem in the treatment of complicated intra-abdominal infections

主要目的：在临床可评价人群中，根据治愈评价访视时的临床疗效在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性。次要目的：根据临床疗效/微生物学疗效，在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性等。

[Translation]

Primary objective: To evaluate the effectiveness of ceftolozane/tazobactam + metronidazole compared with meropenem in subjects with complicated intra-abdominal infection in a clinically evaluable population based on clinical efficacy at the evaluation of cure visit. Secondary objectives: To evaluate the effectiveness of ceftolozane/tazobactam + metronidazole compared with meropenem in subjects with complicated intra-abdominal infection based on clinical efficacy/microbiological efficacy, etc.

Start Date20 Mar 2019

Sponsor / Collaborator

MSD R&D (China) Co. Ltd.

[+2]

100 Clinical Results associated with Metronidazole Hydrochloride

100 Translational Medicine associated with Metronidazole Hydrochloride

100 Patents (Medical) associated with Metronidazole Hydrochloride

16,421

Literatures (Medical) associated with Metronidazole Hydrochloride

01 Jul 2025·Separation and Purification Technology

CuCo carbon aerogel as a bifunctional cathode for Electro-Fenton processes: Unveiling synergistic effects and catalytic mechanisms

Author: Hunter, Timothy N. ; Tillotson, Martin R. ; Ye, Qian ; Harbottle, David ; Kale, Girish M. ; Xu, Hao

Combining electrocatalytic oxygen reduction reaction (ORR) and heterogeneous electro-Fenton (HEF) reaction is considered a promising approach for generating reactive radicals to decompose organic micropollutants in water.A novel catalyst, copper-cobalt carbon aerogel (CuCo/CA), was successfully fabricated and directly applied as a bifunctional cathode in an HEF system.The synergistic effect of Cu and Co contributed to the development of distinctive microstructures, including abundant oxygen-containing groups, carbon defects, a large surface area and a unique porous structure.These structural features endowed CuCo/CA with rapid electron transfer capability and enhanced activity and selectivity for the two-electron ORR process.In the constructed EF system, CuCo/CA achieved its dual functionality by catalyzing the electrosynthesis of hydrogen peroxide and its in situ activation to generate highly reactive hydroxyl radicals.Notably, anodic oxygen evolution in the system eliminated the need for addnl. oxygen input, enhancing its cost-effectiveness.The system demonstrated degradation ability for a range of candidate organic pollutants, including antibiotics, analgesics, organic acid and dye.After six consecutive runs, CuCo/CA EF system achieved satisfactory TC removal and good adaptability within a broad pH range.Long-term stability and low electricity consumption highlighted the potential of CuCo/CA as an efficient and sustainable cathode in EF technol. for water decontamination.

01 Jul 2025·Separation and Purification Technology

Hydroxylamine hydrochloride enhanced Fe-C nano-microelectrolytic material for efficient peracetic acid activation: Proton/electron synergistic effect

Author: Zou, Donglei ; Liu, Yuzhi ; Yu, Haiyang ; Zhong, Shuang ; Cong, Shibo ; Wu, Chuang ; Xia, Shuai

PH and reduction of Fe(III) are the limiting factors of iron-induced advanced oxidation processes.In this study, hydroxylamine hydrochloride (HAH) was employed as a proton (H⁺) and electron donor to adjust pH for ions leaching and reduce Fe(III) to further promote efficiency and reactive species generation in Fe-C nano-microelectrolytic material (nMET)/peracetic acid (PAA) system.It was demonstrated that HAH remarkably boosted Fe(II) recycle and continuous supplied H⁺ to produce organic radicals and hydroxyl radicals in the nMET/HAH/PAA system, based on the consequences of H⁺ and Fe conversion anal., electrochem. experiment, electron para-magnetic resonance spectrometer anal. and quenching test.After the addition of HAH, the degradation efficiency of the nMET/PAA system for metronidazole (MNZ) increased from 31.6% to 84.7%. nMET/HAH/PAA system showed ideal tolerance to wide pH (3.0-9.0), Cl-, NO^-₃ and SO₂^-4, while H₂PO^-₄ inhibited the MNZ degradationFurther, MNZ was transformed into low toxic products through processes of N-denitration, nitro-reduction and ring-opening in the nMET/HAH/PAA process.This research proposed an insight into the role of HAH in the Fe-based advanced oxidation processes for emerging contaminants remediation.

01 Jul 2025·Separation and Purification Technology

Molybdate-loaded magnetic biochar activates persulfate for efficient degradation of sulfamethazine

Author: Xu, Linan ; Fang, Zhanqiang ; Peng, Yifu

Molybdate-doped magnetic biochar (MoMBC) was synthesized using sawdust as the raw material through impregnation and pyrolysis.MoMBC was utilized to activate persulfate (PS) for the degradation of sulfamethazine (SMT).The results demonstrated that at a MoMBC dosage of 0.1 g/L and PS concentration of 2 mM, the MoMBC/PS system exhibited a stabilization of SMT degradation efficiency at a level exceeding 98.1% within 120 min.This was accompanied by a reaction rate constant was 31 times greater than observed in the MBC/PS system.Characterization anal. of MoMBC revealed that molybdate loading facilitated the redox cycling of Fe³⁺/Fe²⁺ and Mo⁶⁺/Mo⁴⁺, thereby enhancing the activation efficiency of PS and accelerating SMT degradationThrough free radical quenching experiments and ESR anal., it was found that the contribution rates of superoxide radicals and hydroxyl radicals were 44.47% and 33.09%, resp., which were the main free radicals promoting the degradation of SMT.Under the coexistence of natural organic matter and anions, the influence of MoMBC/PS system is insignificant.Its powerful broad-spectrum features make it appropriate for the degradation of diverse antibiotics, with a mineralization rate of 59.9%.The degradation of SMT undergoes processes such as oxidation, hydroxylation, and removal of SO₂.This study provides new tech. support for the practical implementation of magnetic biochar in the remediation of water pollution.

100 Deals associated with Metronidazole Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D05016	Metronidazole Hydrochloride	G01AF01 D06BX01 J01XD01 A01AB17 P01AB01	DBSALT000362

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Bacterial Infections	United States	-	28 Nov 1980

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Infections	Preclinical	Jordan	Verisfield (UK) Ltd.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02237950 (CTgov)	Phase 3	Bacterial Vaginosis	586	Metronidazole oral tablets 500mg+1% SPL7013 Gel (1% SPL7013 Gel)	ceezbeiusy(rfldckqvrt) = opewtaagwf xlhyfwlvpr (zipyzrieyt, iwwocwevzk - skdbynblfl) View more	-	09 Jul 2019
				Placebo gel+Metronidazole oral tablets 500mg (Placebo Gel)	ceezbeiusy(rfldckqvrt) = zouwzniyoa xlhyfwlvpr (zipyzrieyt, orjzlnzlwi - okikepttvu) View more

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