While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results.
No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.

Start Date24 Jan 2020

Sponsor / Collaborator

Mansoura University

NCT04462588

/ CompletedNot ApplicableIIT

Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases

After appendectomy was first described by Mcburney in 1889, it has been the most practiced emergency surgery in the world with the lifetime incidence of acute appendicitis being 5%-25%. Most cases are uncomplicated cases without any complications and perforation (20%-30%). Although appendectomy is still a curative therapy, medical treatment has come to the fore in uncomplicated cases after improvements in imaging methods for diagnosing acute appendicitis and especially the developments in antibiotherapy.
Medical treatment for acute appendicitis is, in fact, not a new condition. Practicing the option of elective surgery following intravenous antibiotherapy for plastron appendicitis that is among the complicated acute appendicitis has lead to further consideration of medical treatment. A number of studies conducted for this purpose suggest that conservative treatment in uncomplicated acute appendicitis may be a first-line treatment. Medical treatment of the uncomplicated acute appendicitis prevents negative appendectomies, which indicates that surgical removal of non-inflamed appendix ranging from 6% to 20%. In addition to preventing unnecessary organ loss, it ensures eliminating postoperative complications such as intestinal obstruction and wound site complications due to surgery.
Immature granulocytes (IG) are monitored in peripheral blood as immature polymorphonuclear cells because of the activation of bone marrow. Although their counts can be determined through direct inspection, they can be provided with automated systems within complete blood count parameters as well as technological developments. The increase in their number specifically suggests the activation of the bone marrow and can provide information about the infectious process before leukocytosis is observed.
This study aimed to determine the importance of IG count and percentage to evaluate the role of medical treatment and control its success in cases of uncomplicated acute appendicitis.

Start Date01 Jun 2019

Sponsor / Collaborator

Kahramanmaras Sütçü Imam Üniversitesi

CTR20170435

/ CompletedPhase 3

MK-7625A联合甲硝唑与美罗培南相比治疗复杂性腹腔感染的III期、多中心、双盲、随机、活性药物对照的临床研究

[Translation] A phase III, multicenter, double-blind, randomized, active-controlled clinical study of MK-7625A combined with metronidazole versus meropenem in the treatment of complicated intra-abdominal infections

主要目的：在临床可评价人群中，根据治愈评价访视时的临床疗效在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性。次要目的：根据临床疗效/微生物学疗效，在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性等。

[Translation]

Primary objective: To evaluate the effectiveness of ceftolozane/tazobactam + metronidazole compared with meropenem in subjects with complicated intra-abdominal infection in a clinically evaluable population based on clinical efficacy at the evaluation of cure visit. Secondary objectives: To evaluate the effectiveness of ceftolozane/tazobactam + metronidazole compared with meropenem in subjects with complicated intra-abdominal infection based on clinical efficacy/microbiological efficacy, etc.

Start Date20 Mar 2019

Sponsor / Collaborator

MSD R&D (China) Co. Ltd.

[+2]

100 Clinical Results associated with Metronidazole Hydrochloride

100 Translational Medicine associated with Metronidazole Hydrochloride

100 Patents (Medical) associated with Metronidazole Hydrochloride

16,304

Literatures (Medical) associated with Metronidazole Hydrochloride

01 Jun 2025·Separation and Purification Technology

Long-lasting and efficient peroxydisulfate-based groundwater remediation driven by the slowly released Fe(II) from natural chlorite

Author: Wu, Deli ; Zhou, Zhengwei ; Zong, Yang ; Liu, Hao ; Li, Hongyu ; Zhao, Zhenyu ; Ye, Guojie

The rapid depletion of peroxydisulfate (PDS) and the competitive inactivation of reactive species by excessive Fe restrict the oxidation duration and performance of iron (Fe)-based catalysts activated PDS for in situ chem. oxidation (ISCO).Here, natural chlorite, one of the Fe-rich clay minerals, is used as activator to enhance the performance and efficiency of PDS-based ISCO.It was found that acidification of contaminated groundwater drives the slowly release of aqueous Fe(II) from chlorite and serving as the source of multiple reactive species including hydroxyl radical (.OH), sulfate radical (SO.-4), and Fe(IV).Benefitting from the controlled release of Fe(II), the scavenging of oxidative species by Fe(II) is notably alleviated, leading to the oxidant utilization efficiency of chlorite/PDS improved by 24-95% compared to the Fe(II)/PDS and ZVI/PDS, and the costs of oxidants reduced by over 50%.Long-term experiments indicate that PDS is relatively persistent and slowly consumed by chlorite, hence the oxidative ability for pollution control remains for over one month.This work not only proposes an effective, low-cost and promising alternative process for groundwater remediation, but also demonstrates the significance of slowly released Fe(II) in breaking the trade-off between peroxide activation rate and peroxide utilization efficiency in ISCO.

01 Jun 2025·Separation and Purification Technology

B and P dual sites co-modified g-C3N4 p–n homojunction for photocatalytic CO2 reduction coupled with metronidazole oxidation

Author: Lin, Junyu ; Jia, Xuemei ; Chen, Shifu ; Cao, Jing ; Li, Xinyue ; Lin, Haili

The limited active sites and sluggish reaction kinetics greatly restrict the photocatalytic redox activity for CO₂ reduction coupled with metronidazole (MNZ) oxidationHerein, the electron rich P and electron deficient B were synergistically anchored on graphitic carbon nitride for constructing BPCN p - n homojunction with isolated B and P redox dual - sites, which exhibits an excellent CO yield rate of 3.811μmol g^-1 h^-1 coupled with outstanding MNZ removal rate of 92.60%.The improvement of photocatalytic redox performance was mainly attributed to two aspects: On the one hand, the construction of p - n homojunction effectively accelerated the separation and migration of carriers; On the other hand, the B and P redox dual - sites availably reduced the reaction energy barrier of CO₂ reduction and MNZ oxidation, resp.Besides, the dual - functional coupled reaction system realized the full utilization of photogenerated charges.This work not only offers new insight for designing efficient p - n homojunction with redox double sites, but also confirms the potential application for congenerous environment renovation and energy conversion.

01 Jun 2025·Separation and Purification Technology

Electronically regulated Mn-N site-loaded MXenes for highly efficient and selective singlet oxygen generation via PMS activation

Author: Liu, Zhen ; Yuan, Shiyu ; Zheng, Peng ; Gao, Shikun ; Yuan, Shaochun ; Chen, Yao ; Yang, Shanshan ; Zhang, Zhe ; Ji, Fangfang

In this study, a novel catalyst featuring dual-reactive sites of transition metal and nonmetal is presented, which modifies electronic polarization to enhance the selective generation of singlet oxygen (¹O₂), resulting in effective degradation of antibiotics.Using MXenes as a substrate, a structurally stable Mn-N@MXenes catalyst with controllable reactive sites was synthesized via a hydrothermal method by adjusting the content of the Mn-N precursor.The study revealed that the loading of Mn-N active sites changes the electronic structure and polarization of MXenes, resulting in asym. electronic structures and the generation of numerous oxygen vacancies.These characteristics enable the Mn-N@MXenes/PMS system to selectively generate ¹O₂ and superoxide radicals (O^•-₂), with a synergistic index of 5.77.Compared to the MXenes/PMS system, the Mn-N@MXenes/PMS system significantly boosts the degradation efficiency of ofloxacin (OFL) from 71.32% to 96.07% under optimal conditions.The results demonstrate that during PMS activation, the catalyst maintains a nearly constant degradation rate after four cycles, exhibiting excellent stability and recyclability.Furthermore, the system shows superior performance and environmental adaptability in degrading actual water matrixes and other pollutants.This study reveals electronic regulation mechanisms in catalyst design that facilitate pollutant degradation via both radical and non-radical pathways, offering new strategies for efficient degradation

100 Deals associated with Metronidazole Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D05016	Metronidazole Hydrochloride	G01AF01 D06BX01 J01XD01 A01AB17 P01AB01	DBSALT000362

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Infections	United States	-	28 Nov 1980

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Infections	Preclinical	Jordan	Verisfield (UK) Ltd.	-

Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02237950 (CTgov)	Phase 3	Bacterial Vaginosis	586	Metronidazole oral tablets 500mg+1% SPL7013 Gel (1% SPL7013 Gel)	disndtjeoe(dljhpqvpch) = aqdtdirhjl nizpprlujf (lkrqbyzphn, elerjgoknr - esqxqeiqyd) View more	-	09 Jul 2019
				Placebo gel+Metronidazole oral tablets 500mg (Placebo Gel)	disndtjeoe(dljhpqvpch) = eykkoudllt nizpprlujf (lkrqbyzphn, xteluiogpu - qnbrfwxtfc) View more

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