Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications

Author: Mothana, Ramzi A. ; Hbika, Asmae ; Farihi, Ayoub ; Gharibi, Elkhadir ; Ed-darraz, Fatima-Zahrae ; Hawwal, Mohammed F. ; Benali, Mohammed ; Bouyanzer, Abdelhamid

Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavor, has been used in a variety of culinary applications.This study investigates its metabolites through phytochem. methods.The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content.The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE.The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content.Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the Et acetate extract (42.4%).Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, Et acetate, and ethanol extracts, resp.ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.

31 Dec 2025·Plant Signaling & Behavior

Comparative effects of biocontrol agent and pathogen on Nicotiana tabacum : insights into fungal-plant interactions

Article

Author: Wang, Hui ; Jaisi, Amit ; Wu, Dongling ; Ren, Zhichao ; Yang, Mengquan ; Feng, Zhao ; Yin, Quanyu ; Zhu, Zhengkang

Tobacco (Nicotiana tabacum) black shank disease, caused by Phytophthora nicotianae, is a significant threat to tobacco crops, leading to severe economic losses. Prolonged use of agrochemicals to control this disease has prompted the exploration of eco-friendly biological control strategies. This study investigated the effects of Trichoderma harzianum, a biocontrol agent, on N. tabacum in comparison to P. nicotianae, focusing on growth, biomass, root morphology and anatomy, hormonal changes, and osmotic regulation. T. harzianum significantly enhanced plant growth, biomass accumulation, root system development, and physiological attributes such as photosynthetic pigment levels and antioxidant enzyme activity. In contrast, P. nicotianae negatively impacted these parameters, inhibiting growth and physiological function. Notably, T. harzianum increased proline content and enhanced induced resistance mechanisms, mitigating stress and promoting overall plant health. These findings highlight the potential of T. harzianum as a sustainable solution for managing black shank disease while improving tobacco crop productivity.

31 Dec 2025·Plant Signaling & Behavior

The biochemical and molecular mechanisms of plants: a review on insect herbivory

Review

Author: Babalola, Olubukola Oluranti ; Aanaenson, Mari ; Adedayo, Afeez Adesina ; Musser, Richard

Biochemical and molecular mechanisms have been essential mechanisms to reduce various insect attacks on plants. The biochemical methods are wide involving direct and indirect defenses. The defensive chemical substances are secreted effectively to the wound caused by the herbivores (insects and phytopathogens) on plants. Plants responded by producing VOCs which draw the natural enemies of the insects and phytopathogens. The progress observed in the cognition of the stimulus in plants and their potential to control the responses is characterized by the modification observed in molecular mechanisms which shifts our attention to the development of the endogenous resistance methods of preserving crops. The main objective of implementing a biotechnological mechanism in crop production is to employ durable and multimechanistic alternatives to insect pests via the stimulus the plant produces upon encountering the insect attack.

100 Deals associated with Magnesium Salicylate

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KEGG	Wiki	ATC	Drug Bank
D00827	Magnesium Salicylate	N02BA	DB01397

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10 top approved records.

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Indication	Country/Location	Organization	Date
Arthritis	China	China Pharmaceutical University Pharmaceutical Co. Ltd.	01 Jan 1985
Bursitis	China	China Pharmaceutical University Pharmaceutical Co. Ltd.	01 Jan 1985
Soft tissue rheumatism	China	China Pharmaceutical University Pharmaceutical Co. Ltd.	01 Jan 1985

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