A Phase I and Pharmacokinetic Study of NM-3 Administered Orally Once or Twice Daily on Five Consecutive Days and Repeated Weekly for Six Weeks Every Eight Weeks in Patients With Advanced Solid Tumors.

A study for patients who have failed standard therapy. If there is no dose limiting toxicities the patients will receive further cycles of therapy if there is no evidence of disease progression.

Start Date01 May 2001

Sponsor / Collaborator

Genzyme Corp.

100 Clinical Results associated with NM-3

100 Translational Medicine associated with NM-3

100 Patents (Medical) associated with NM-3

Literatures (Medical) associated with NM-3

01 Jun 2024·Data in Brief

Dataset on utilizing cropping system-based fertilization techniques to improve soil health and crop output while minimizing tillage

Article

Author: Mondol, A T M Anwarul Islam ; Islam, Mahammad Shariful ; Smiriti, Rabeka Sultana ; Alam, Zakaria ; Naser, Habib Mohammad ; Akter, Sanjida ; Alam, Md Jahangir

The dataset provided details on how tillage methods and nutrient management impacted the productivity of the four crops (mustard>mungbean>Transplanting (T.) aus >Transplanting (T.) aman) cropping system and the overall soil health. The specific tillage techniques examined were minimum tillage (MT), conventional tillage (CT), and deep tillage (DT). Regarding nutrient management, NM₁ utilized 100 % soil test-based (STB) fertilization following fertilizer gradient generation (FRG); NM₂ applied 125 % of STB after FRG-2018; NM₃ consisted of 100 % STB (with 80 % from chemical fertilizers and 20 % from cow dung); and NM₄ relied on native fertility without any fertilization. Over three consecutive seasonal years (2018-19, 2019-20, and 2020-21), twelve treatments were replicated three times following a factorial totally randomized design. The comparative analysis of crop yield, rice equivalent yield, system productivity and production efficiency indicated superior performance of MT over both CT and DT. Furthermore, in relation to agricultural productivity metrics, the application of the nutrition package NM₃ demonstrated performance levels exceeding the average. The adoption of MT and the incorporation of the NM₃ nutrition package led to notable advancements in organic matter, field capacity, microbial biomass nitrogen, microbial biomass carbon and soil nutrient levels (N, P, K, S, Zn, and B). Consequently, the synthesis of the NM₃ with MT is posited as a strategic approach for soil enhancement and the augmentation of crop productivity.

01 Jan 2024·Heliyon

Cropping system-based fertilizer strategies for crop productivity and soil health under minimum tillage in grey terrace soil

Article

Author: Naser, Habib Mohammad ; Islam, Md Mazadul ; Alam, Zakaria ; Akter, Sanjida ; Mondol, A T M Anwarul Islam ; Salahin, Nazmus ; Alam, Md Jahangir ; Islam, Mahammad Shariful ; Alam, Md Khairul

A cropping system that is based on three or four crops is currently a widely favored option for augmenting crop productivity to address the escalating global food demand. However, the improper fertilizer management and undue tillage adversely impacts both the productivity of crops and the fertility of the soil. A research investigation was conducted on tillage and nutrient management within the mustard-mungbean-Transplanting aus (T.aus)-Transplanting aman (T.aman) cropping system to examine the impact of fertilizer packages and tillage techniques on the overall productivity of cropping systems, as well as the condition of the soil in grey terrace soil. The research included tillage techniques viz; minimum tillage (MT), conventional tillage (CT) and deep tillage (DT); while nutrient management; NM₁: 100 % STB (Soil test based) following FRG (Fertilizer Recommendation Guide-2018), all from chemical fertilizer, NM₂: 125 % of STB following FRG- 2018, all from chemical fertilizer, NM₃: 100 % STB (80 % from chemical fertilizers and 20 % from cowdung), and NM₄: Native fertility (no fertilization). A total of twelve treatments replicated three times following the factorial completely randomized design for three consecutive seasonal years (2018-19, 2019-20, and 2020-21). MT outperformed DT and CT in terms of crop yield, rice equivalent yield (REY), system productivity (SP), and production efficiency (PE). Moreover, NM₃ exhibited enhanced performance in terms of agricultural productivity measures. Field capacity (FC), soil organic matter (OM), microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), and soil nutrients (N, P, K, S, Zn and B) observed an enhancement as a result of the implementation of tillage MT and nutrition package NM₃. The investigation indicates that implementing minimum tillage (MT) coupled with an integrated plant nutrition system package (NM3) can assist in the improvement of soil and the enhancement of crop productivity.

01 Jan 2007·World Journal of GastroenterologyQ3 · MEDICINE

Molecular mechanisms of paclitaxel and NM-3 on human gastric cancer in a severe combined immune deficiency mice orthotopic implantation model

Q3 · MEDICINE

Article

Author: Qin ; Ming-Quan ; Li ; Song ; Chen ; Zhang ; Qiang ; Jin-Shui ; Sun ; Guo-Qiang ; Qun ; Zhu

AIMTo explore the molecular mechanisms of action of paclitaxel and NM-3 on human gastric cancer in severe combined immune deficiency (SCID) mice.METHODSHuman gastric cancer cells SGC-7901 were implanted into SCID mice and mice were treated with paclitaxel and NM-3. The effects of paclitaxel and NM-3 on apoptosis of human gastric cancer cells were analyzed using flow cytometry, TUNEL assays, and DNA fragment analyses.RESULTSApoptosis of SGC-7901 cells was successfully induced by paclitaxel, NM-3, and the combination of paclitaxel and NM-3 24 h after injection as shown by the presence of apoptotic hypodiploid peaks on the flow cytometer before G1-S and a characteristic apoptotic band pattern in the DNA electrophoresis. The apoptotic rate detected by TUNEL assay was found to be significantly higher in the paclitaxel/NM-3 compared to the control group (38.5% +/- 5.14% vs 13.2% +/- 1.75%, P < 0.01).CONCLUSIONPaclitaxel in combination with NM-3 is able to induce apoptosis of the human gastric cancer cells in SCID mice effectively and synergistically.

100 Deals associated with NM-3

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Malignant Solid Neoplasm	Phase 1	US	Genzyme Corp.	01 May 2001
Rheumatoid Arthritis	Phase 1	JP	Mercian Corp.	-
Rheumatoid Arthritis	Phase 1	-	Mercian Ltd.	-
Rheumatoid Arthritis	Phase 1	-	Genzyme Corp.	-
Solid tumor	Phase 1	JP	Mercian Corp.	-

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