Delving into the Latest Updates on DA-023 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

EAAT2

Mechanism

EAAT2 modulators(solute carrier family 1 member 2 modulators)

Therapeutic Areas

Nervous System Diseases

Active Indication

Central Nervous System Diseases

Inactive Indication-

Originator Organization

Drexel University College of Medicine

Active Organization

Drexel University College of Medicine

Inactive Organization-

Drug Highest PhaseDiscovery

First Approval Date-

Regulation-

Structure

Molecular FormulaC20H25N7

InChIKeyVGNIHZIDQKBDHQ-UHFFFAOYSA-N

CAS Registry2585643-97-4

4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M) in the presence of 1.0 x 10(-10) M Am80 (2).

01 Jul 1983·The Journal of General PsychologyQ4 · PSYCHOLOGY

Pattern Memory and Resistance to Extinction in Double Alternating Reinforcement

Q4 · PSYCHOLOGY

Article

Author: Ishida, Masato

Interval between acquisition and extinction (A-E interval) was varied in order to investigate effects of regularly alternated partial reinforcement on resistance to extinction and to assess the notion of pattern memory which was suggested on the basis of single alternation study. Random alternation (RA) and double alternation (DA) groups were trained with extensive trials and then extinguished under one-day's (RA1, DA1) or 23-days' (RA23, DA23) A-E interval. RA1 was more resistant to extinction than DA1, but DA23 did not differ from RA23. Moreover, extinction performance of DA schedule was retained well in spite of the extension of A-E interval, unlike that of RA schedule. These extinction results cannot be interpreted consistently even by the N-length variables. The persistence of DA schedule shown in delayed extinction was discussed in terms of the pattern memory assumption.

100 Deals associated with DA-023

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