Mucolytic effects of domiodol in tracheostomized patients after total laryngectomy. Double-blind, placebo-controlled, randomized pilot study with four-month follow-up.

Article

Author: Antonelli, A ; Garrubba, V ; Donati, C ; Carraro, A

The results obtained in a controlled clinical trial aimed at evaluating the efficacy and tolerability of a mucolytic treatment in laryngectomized patients are described. Domiodol (Mucolitico Maggioni, CAS 61869-07-6), an organic iodinated mucolytic agent, was given at the dosage of 60 mg t.i.d. to 20 patients in the post-operative period after laryngectomy (average 2 weeks in hospital and 4 months follow-up at home). A matched series of patients received a placebo during the hospital period and no treatment after discharge. The patients receiving the active treatment showed a statistically and clinically significant improvement of respiratory parameters (cough intensity, sputum quantity, sputum quality, expectoration difficulty). Such improvement was earlier and greater than that observed in the placebo-treated patients. It is concluded that a mucolytic treatment may be helpful in the post-operative treatment of laryngectomized patients with permanent tracheostomy.

01 Jan 1988·Journal of International Medical ResearchQ4 · MEDICINE

Domiodol Treatment for Bronchopulmonary Diseases in the Paediatric Age Group: A Double-Blind Controlled Clinical Trial versus Placebo

Q4 · MEDICINE

ArticleOA

Author: Zuccotti, G. ; Fiocchi, A. ; Giovannini, M. ; Arancio, R. ; Riva, E. ; Grasso, U.

Thirty children (25 males, five females), mean age 9.33 ± 2.57 years, with acute infectious pulmonary diseases or acute flare-ups of chronic bronchitis, were randomly treated with either domiodol or placebo. The study was conducted between November 1986 and February 1987. Domiodol was administered orally for 14 days in doses of 0.5 mg/kg three times daily. Subjective symptoms (cough, sputum viscosity, difficulty in raising sputum and sputum characteristics) were assessed semi-quantitatively. They were all reduced significantly in the group treated with domiodol compared to those given placebo. Spirometric measures of vital capacity and peak expiratory flow rate were also improved in patients given domiodol compared with placebo. Conversely, no differences were noted in forced expiratory volume in 1 s, Tiffenau index, or mid-expiratory flow. There were no clinical side-effects and no changes in any other parameters measured; in particular, levels of thyroid hormone and thyroid stimulating hormone were unchanged. Thus, domiodol proved effective in reducing the symptoms of infection of the lower respiratory tract and in improving the consistency of mucus in children.

01 Sep 1984·Il Farmaco; edizione pratica

Absorption, distribution, excretion and metabolism of domiodol.

Article

Author: Takaichi, M ; Kato, R ; Yokoshima, T ; Jin, Y ; Ohtsuki, T

100 Deals associated with Domiodol

External Link

KEGG	Wiki	ATC	Drug Bank
-	Domiodol	R05CB08	DB13768

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