Randomized Controlled Trial of COVID-19 booster vaccine for intramuscular versus subcutaneous administration assessing immunogenicity and reactogenicity. in pharmacies/vaccination sites in Aotearoa, New Zealand.

Start Date30 Mar 2024

Sponsor / Collaborator

Medical Research Institute of New Zealand

TCTR20240708002 / CompletedNot ApplicableIIT

Antibody Response in People living with HIV Comparing CD4 T-cell Levels more than 200 vs. lower or equal 200 cells/mm3 after mRNA COVID-19 Vaccine Booster

Start Date01 Apr 2023

Sponsor / Collaborator-

100 Clinical Results associated with mRNA COVID-19 Booster Vaccine (Esperovax)

100 Translational Medicine associated with mRNA COVID-19 Booster Vaccine (Esperovax)

100 Patents (Medical) associated with mRNA COVID-19 Booster Vaccine (Esperovax)

119

Literatures (Medical) associated with mRNA COVID-19 Booster Vaccine (Esperovax)

31 Dec 2024·Human Vaccines & Immunotherapeutics

Factors associated with the COVID-19 booster vaccine intentions of young adults in the United States

Article

Author: Bauermeister, José ; Yu, Hyunmin ; Aryal, Subhash ; Glanz, Karen ; Villarruel, Antonia ; Kornides, Melanie ; Bonett, Stephen ; Oyiborhoro, Ufuoma

Young adults experience high coronavirus disease 2019 (COVID-19) incidence yet have the lowest vaccination and booster rates among adults. Understanding the factors influencing their intentions regarding boosters is essential for crafting effective public health strategies. We examined the psychosocial factors (attitudes, norms, perceived behavioral control) associated with their intentions to receive a COVID-19 booster. This cross-sectional study included 292 young adults aged 18-25 residing in Philadelphia who completed an online survey from September 2021 and February 2022 (mean age 21.98, standard deviation 2.25; 51% racial/ethnic minorities). The survey included measures of attitudes, norms, and perceived behavioral control related to COVID-19 vaccination. We employed structural equation modeling analysis to examine the intention of young adults to receive the COVID-19 booster and their vaccine-related attitudes, norms, and perceived behavioral control. Covariates included race/ethnicity and gender. Subjective norms were significantly associated with the intention to receive a COVID-19 booster (standardized β̂ = 0.685, p = .018). Attitudes and perceived behavioral control showed no significant association with intention. Subgroup analyses based on race/ethnicity revealed that attitudes (standardized β̂ = 0.488, p = .004) and subjective norms (standardized β̂ = 0.451, p = .050) were predictors among young adults from racial and ethnic minority backgrounds, while only subjective norms (standardized β̂ = 1.104, p = .002) were significant for non-Hispanic White young adults. Public health efforts should prioritize engaging healthcare providers and peer groups in order to influence subjective norms and promote collective responsibility and acceptance for vaccination. Tailored interventions and diverse communication strategies targeting specific subgroups of young adults may be useful to ensure comprehensive and effective vaccination initiatives.

31 Dec 2024·Human Vaccines & Immunotherapeutics

No immunological interference or concerns about safety when seasonal quadrivalent influenza vaccine is co-administered with a COVID-19 mRNA-1273 booster vaccine in adults: A randomized trial

Article

Author: Anteyi, Kate ; Naficy, Abdi ; Mwakingwe-Omari, Agnes ; Seifert, Harry ; Hastie, Andrew ; Leav, Brett ; Miller, Jacqueline ; Kuxhausen, Adrienne

The objective of the study was to assess the safety and immunogenicity of mRNA-1273 COVID-19 booster vaccination when co-administered with an egg-based standard dose seasonal quadrivalent influenza vaccine (QIV). This was a phase 3, randomized, open-label study. Eligible adults aged ≥ 18 years were randomly assigned (1:1) to receive mRNA-1273 (50 µg) booster vaccination and QIV 2 weeks apart (Seq group) or concomitantly (Coad group). Primary objectives were non-inferiority of haemagglutinin inhibition (HI) and anti-Spike protein antibody responses in the Coad compared to Seq group. 497/498 participants were randomized and vaccinated in the Seq/Coad groups, respectively. The adjusted geometric mean titer/concentration ratios (95% confidence intervals) (Seq/Coad) for HI antibodies were 1.02 (0.89-1.18) for A/H1N1, 0.93 (0.82-1.05) for A/H3N2, 1.00 (0.89-1.14] for B/Victoria, and 1.04 (0.93-1.17) for B/Yamagata; and 0.98 (0.84-1.13) for anti-Spike antibodies, thus meeting the protocol-specified non-inferiority criteria. The most frequently reported adverse events in both groups were pain at the injection site and myalgia. The 2 groups were similar in terms of the overall frequency, intensity, and duration of adverse events. In conclusion, co-administration of mRNA-1273 booster vaccine with QIV in adults was immunologically non-inferior to sequential administration. Safety and reactogenicity profiles were similar in both groups (clinicaltrials.gov NCT05047770).

31 Dec 2024·Human Vaccines & Immunotherapeutics

How urban versus rural population relates to COVID-19 booster vaccine hesitancy: A propensity score matching design study

Article

Author: Zhao, Qiuping ; Dong, Wenyong ; Hu, Jianping ; Guo, Dan ; Zhang, Jingbao ; Li, Yi ; Wei, Wei ; Bai, Junwen ; Zhang, Wanliang ; Ren, Ruizhe ; Miao, Yudong ; Zhu, Dongfang ; Li, Miaojun ; Tarimo, Clifford Silver ; Liu, Rongmei ; Shen, Zhanlei

During the COVID-19 pandemic, the vaccine hesitancy has significantly affected the vaccination. To evaluate the booster vaccine hesitancy and its influencing factors among urban and rural residents, as well as to estimate the net difference of booster vaccine hesitancy between urban and rural residents. We conducted a nationwide, cross-sectional Internet survey on 1-8 February 2023, and employed stratified random sampling technique to select participants (≥18 years old) from urban and rural areas. Multivariate logistic regression was used to determine the factors impacting booster vaccine hesitancy. Propensity Score Matching was used to estimate the net difference of COVID-19 booster vaccine hesitancy between urban and rural residents. The overall COVID-19 booster vaccine hesitancy rate of residents was 28.43%. The COVID-19 booster vaccine hesitancy rate among urban residents was found to be 34.70%, among rural residents was 20.25%. Chronic diseases, infection status, vaccination benefits, and trust in vaccine developers were associated with booster vaccine hesitancy among urban residents. Barriers of vaccination were associated with booster vaccine hesitancy among rural residents. PSM analysis showed that the urban residents have a higher booster vaccine hesitancy rate than rural residents, with a net difference of 6.20%. The vaccine hesitancy rate increased significantly, and the urban residents have a higher COVID-19 booster vaccine hesitancy than rural residents. It becomes crucial to enhance the dissemination of information regarding the advantages of vaccination and foster greater trust among urban residents toward the healthcare system.

100 Deals associated with mRNA COVID-19 Booster Vaccine (Esperovax)

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Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Preclinical	US	Esperovax, Inc.Startup	31 Aug 2023

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