Last update 06 Jun 2025

Nivolumab/Relatlimab/Hyaluronidase

Overview

Basic Info

Drug Type
Monoclonal antibody, Enzyme
Synonyms
Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination
Target
Hyaluronic acid x LAG3 x PD-1
Action
modulators, inhibitors, stimulants
Mechanism
Hyaluronic acid modulators, LAG3 inhibitors(Lymphocyte activation gene 3 protein inhibitors), PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Therapeutic Areas
NeoplasmsSkin and Musculoskeletal Diseases
Active Indication
Metastatic melanoma
Inactive Indication-
Originator Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Active Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Related

4
Clinical Trials associated with Nivolumab/Relatlimab/Hyaluronidase
CTRI/2025/03/083121
/ Not yet recruitingPhase 3
A Phase 3, Randomized, open-label Study of Nivolumab + Relatlimab Fixed-dose Combination with Chemotherapy Versus Pembrolizumab with Chemotherapy as First-line Treatment for Participants with Non-squamous (NSQ), Stage IV or Recurrent Non-small Cell Lung Cancer and with Tumor Cell PD-L1 expression of 1% to 49%
NCT06101134
/ Active, not recruitingPhase 2
A Phase 2 Open-label, Two-cohort Study to Evaluate Patient Preference for Nivolumab + Relatlimab Fixed-dose Combination Subcutaneous Versus Nivolumab + Relatlimab Fixed-dose Combination Intravenous and Nivolumab Subcutaneous Versus Nivolumab Intravenous in Participants With Melanoma
CTIS2022-500967-11-00
/ RecruitingPhase 3
A Phase 3, Randomized, Open-label, Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination versus Intravenous Nivolumab + Relatlimab Fixed-dose Combination in Participants with Previously Untreated Metastatic or Unresectable Melanoma - CA224-127
100 Clinical Results associated with Nivolumab/Relatlimab/Hyaluronidase
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100 Translational Medicine associated with Nivolumab/Relatlimab/Hyaluronidase
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100 Patents (Medical) associated with Nivolumab/Relatlimab/Hyaluronidase
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100 Deals associated with Nivolumab/Relatlimab/Hyaluronidase
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic melanomaPhase 2
United States
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Nov 2023
Metastatic melanomaPhase 2
Chile
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Nov 2023
Metastatic melanomaPhase 2
Greece
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Nov 2023
Metastatic melanomaPhase 2
Italy
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Nov 2023
Metastatic melanomaPhase 2
Spain
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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