Drug Type Small molecule drug  | 
Synonyms HEP-50768  | 
Target  | 
Action antagonists  | 
Mechanism MRGPRX4 antagonists(MAS related GPR family member X4 antagonists)  | 
Therapeutic Areas  | 
Active Indication  | 
Inactive Indication-  | 
Originator Organization  | 
Active Organization  | 
Inactive Organization-  | 
License Organization-  | 
Drug Highest PhaseIND Approval  | 
First Approval Date-  | 
Regulation-  | 
| Indication | Highest Phase | Country/Location | Organization | Date | 
|---|---|---|---|---|
| Chronic Kidney Disease-Associated Pruritus | IND Approval | China   | 28 Sep 2025 | |
| Cholestatic pruritus | IND Approval | United States   | 07 Aug 2025 | 





