Last update 20 Apr 2026

HEP-50768

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HEP-50768
Target
MRGPRX4
Action
antagonists
Mechanism
MRGPRX4 antagonists(MAS related GPR family member X4 antagonists)
Therapeutic Areas
Skin and Musculoskeletal DiseasesUrogenital Diseases
Active Indication
Cholestatic pruritusChronic Kidney DiseasesChronic Kidney Disease-Associated Pruritus
Inactive Indication-
Originator Organization
Haipaitec (Beijing) Biomedical Technology Co., Ltd.
Active Organization
Haipaitec (Beijing) Biomedical Technology Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with HEP-50768
CTR20261473
/ Not yet recruitingPhase 1
一项评估HEP-50768在健康试验参与者、胆汁淤积性瘙痒试验参与者和慢性肾病相关性瘙痒试验参与者中的安全性、耐受性和药代动力学特征的随机、单多次给药剂量递增的I期研究
[Translation] A randomized, single- or multiple-dose escalation phase I study evaluating the safety, tolerability, and pharmacokinetic characteristics of HEP-50768 in healthy participants, participants in cholestatic pruritus trials, and participants in chronic kidney disease-associated pruritus trials.
100 Clinical Results associated with HEP-50768
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100 Translational Medicine associated with HEP-50768
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100 Patents (Medical) associated with HEP-50768
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100 Deals associated with HEP-50768
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cholestatic pruritusPhase 1
China
Haipaitec (Beijing) Biomedical Technology Co., Ltd.
20 Apr 2026
Chronic Kidney DiseasesPhase 1
China
Haipaitec (Beijing) Biomedical Technology Co., Ltd.
20 Apr 2026
Chronic Kidney Disease-Associated PruritusIND Approval
China
Haipaitec (Beijing) Biomedical Technology Co., Ltd.
28 Sep 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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